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Database: UniProt
Entry: B4MMD0_DROWI
LinkDB: B4MMD0_DROWI
Original site: B4MMD0_DROWI 
ID   B4MMD0_DROWI            Unreviewed;      1235 AA.
AC   B4MMD0;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   27-SEP-2017, entry version 69.
DE   SubName: Full=Uncharacterized protein, isoform D {ECO:0000313|EMBL:EDW73275.2};
GN   Name=Dwil\GK17464 {ECO:0000313|EMBL:EDW73275.2};
GN   ORFNames=Dwil_GK17464 {ECO:0000313|EMBL:EDW73275.2}, GK17464
GN   {ECO:0000313|FlyBase:FBgn0219463};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW73275.2, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW73275.2, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
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DR   EMBL; CH963847; EDW73275.2; -; Genomic_DNA.
DR   RefSeq; XP_002062289.2; XM_002062253.2.
DR   GeneID; 6638751; -.
DR   KEGG; dwi:Dwil_GK17464; -.
DR   FlyBase; FBgn0219463; Dwil\GK17464.
DR   eggNOG; KOG0510; Eukaryota.
DR   eggNOG; COG0666; LUCA.
DR   InParanoid; B4MMD0; -.
DR   KO; K04984; -.
DR   OrthoDB; EOG091G01BG; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0009408; P:response to heat; IEA:EnsemblMetazoa.
DR   CDD; cd00204; ANK; 4.
DR   Gene3D; 1.25.40.20; -; 5.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF12796; Ank_2; 4.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 14.
DR   SUPFAM; SSF48403; SSF48403; 3.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 10.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00844120}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    789    811       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    863    881       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    893    915       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    927    948       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    968    990       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1010   1031       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1043   1066       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    640       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      128    160       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      161    193       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      229    250       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      304    336       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      375    407       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      408    440       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      481    513       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      514    536       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      550    582       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      616    640       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   COILED     1153   1176       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1235 AA;  139233 MW;  BBF89B8AC7FCE423 CRC64;
     MPKLYNGVFN GQCDSLSQQD IMEAQPKLLP KTRSNSGSNS GSASNRNSKY WIFSMIIERS
     AGSKRLEIGN DIDTPLEAIL PAEPPAEQVC LLRDSPYRIL RAAESGNLDD FKRLFMADNT
     RIALKDGKGR TAAHQAAARN RVNILSYIRD QSGDFNAKDN AGNTPLHIAV ECDAYDALDY
     LLSIPVDTGI LNEKKQAPVH LATELNKVKS LQVMGQYRNV IDIQQGGEHG RTALHLAAIY
     DHEECARILI TEFDACPRRP CNNGYYPIHE AAKNASSKTM EVFFQWGEQR GCTREEMISF
     YDSEGNVPLH SAVHGGDIKA VELCLKSGAK ISTQQHDLST PVHLACAQGA IDIVKLMFEM
     QPLEKRICLS CTDVQKMTPL HCASMFDHPD IVSYLVAEGA DINALDKEHR SPLLLAASRS
     GWKTVHLLIR LGACISVKDA AARNVLHFVI MNGGRLTDFA EQVAKCQTQE LKLLLNEKDN
     MGCSPLHYAS RDGHIRSLEN LIRLGACINL KNNNNESPLH FAARYGRYNT VRQLLDSEKG
     SFIINESDGA GMTPLHIASQ QGHTRVVQLL LNRGALLHRD HSGRNPLQLA AMSGYTETIE
     LLHSVHSHLL DQVDKDGNTA LHLATMENKP HAISVLMSMG CKLVYNILDM SAIDYAIYYK
     YPEAALAMVT HEERANEVIA LRSDKHPCVT LALIASMPKV FEAVQDKCIT KANCKKDSKS
     FYIKYSFAFL QCPYLFAKID EKTGEPIMTT NPIPLPALNT MVTHGRVELL AHPLSQKYLQ
     MKWNSYGKYF HLANLLVYSI FLVFVTIYSS LMMNNIELRA EGNKTMSQYC NMGWDQLTQN
     LSQNPSVATQ IRLDSCVEHI NRTTAILFCA VIVVVYILLN SMRELIQIYQ QRLHYLVETV
     NLISWVLYIS ALVMIQPAFR ADGAINTIHY SAASIAVFLS WFRLLLFLQR FDQVGIYVVM
     FLEILQTLIK VLMVFSILII AFGLAFYILL SKIIDPQPNH LSFSNIPMSL LRTFSMMLGE
     LDFVGTYVNT YYRDQLKVPM TSFLILSVFM ILMPILLMNL LIGLAVGDIE SVRRNAQLKR
     LAMQVVLHTE LERKLPHVWL QRVDKMELIE YPNETKCKIG ICDFILRKWF SNPFTEDSSM
     DVISFDNNDD YINAELERQR RKLRDISRML EQQHQLVRLI VQKMEIKTEA DDVDEGISPN
     ELRLVAGLGS AGGNRWNSPR IRNKLRAALS FNKSL
//
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