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Database: UniProt
Entry: B4MTG3_DROWI
LinkDB: B4MTG3_DROWI
Original site: B4MTG3_DROWI 
ID   B4MTG3_DROWI            Unreviewed;      2140 AA.
AC   B4MTG3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   25-OCT-2017, entry version 65.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW75402.2};
GN   Name=Dwil\GK20157 {ECO:0000313|EMBL:EDW75402.2};
GN   ORFNames=Dwil_GK20157 {ECO:0000313|EMBL:EDW75402.2}, GK20157
GN   {ECO:0000313|FlyBase:FBgn0222154};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW75402.2, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW75402.2, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH963851; EDW75402.2; -; Genomic_DNA.
DR   RefSeq; XP_002064416.2; XM_002064380.2.
DR   STRING; 7260.FBpp0249300; -.
DR   GeneID; 6641191; -.
DR   KEGG; dwi:Dwil_GK20157; -.
DR   FlyBase; FBgn0222154; Dwil\GK20157.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; B4MTG3; -.
DR   KO; K21863; -.
DR   OrthoDB; EOG091G00F9; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0043679; C:axon terminus; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043025; C:neuronal cell body; IEA:EnsemblMetazoa.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0045475; P:locomotor rhythm; IEA:EnsemblMetazoa.
DR   GO; GO:0042752; P:regulation of circadian rhythm; IEA:EnsemblMetazoa.
DR   GO; GO:0072347; P:response to anesthetic; IEA:EnsemblMetazoa.
DR   GO; GO:0050975; P:sensory perception of touch; IEA:EnsemblMetazoa.
DR   GO; GO:0035176; P:social behavior; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.565.10; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   InterPro; IPR035500; NHR_like_domain.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 2.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    371    392       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    440    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    563    586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    652    672       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    684    707       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    719    737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    775    798       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    842    865       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1161   1185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1205   1223       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1235   1254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1297   1316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1413   1436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1494   1513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1519   1537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1579   1595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1615   1636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1702   1724       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      303    596       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      648    869       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1167   1441       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1489   1735       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   2140 AA;  240227 MW;  4B664257D93C928A CRC64;
     MIDRLQIRRL GAAARNKRTG GSGSGSFHSH TPHSASGINT PATASTSSSS GNSLTPQQQQ
     QQQQQQHQQQ QQQQHHPHSH LHTHPHPHHS HGQQHTAHHQ HPHQHQHTHH PHQRSSQAPQ
     AFSFNPSPGS SPGNGLEATS RGGQHAVSAL NSPIVNSASS TGMQQQQQQQ QQIGSGSSTA
     ATAAVGGSNG AGTTSGALPV GVGGGGLNLL GGIGGLGGMG GGAAAAAGMG ICGGISSTVG
     SAAITGVPPL GLGIATGIGN KIMLGRKQSL KGGEPFLADY GPEESLNESA DIEWVNKLWV
     RRLMRMCALI SLTSVSLNTP KTFERYPALQ YITFVSDTAV TLLFTAEMIA KMHIRGVLHG
     EVPYLKDHWC QFDASMVSFL WVSIILQIFE VLEIVAKFSY LSIMRAPRPL IMIRFLRVFL
     KFSMPKSRIN QIFKRSSQQI YNVTLFFLFF MSLYGLLGVQ FFGELKNHCV MNNTEYDVLG
     RPVLTINSLA IPDTFCSMDP DSGYQCSPGM RCMKMDFLSS YVIGFNGFED IATSIFTVYQ
     AASQEGWVFI MYRAIDSLPA WRAAFYFSTM IFFLAWLVKN VFIAVITETF NEIRVQFQQM
     WGARGHIQKT AASQILSGND TGWRLVTIDD NKHGGLAPET CHAILRSPYF RMLVMTVILA
     NGIVTATMAF KHDGRPRHVF YERYYYIEVV FTCLLDLETL FKIYCLGWRG YYKHSIHKFE
     LLLAAGTTLH IVPMFYLSGL TYFQVLRVVR LIKASPMLEG FVYKIFGPGK KLGSLIIFTM
     CLLIISSSIS MQLFCFLCDF TKFESFPEAF MSMFQILTQE AWVEVMDETM IRTSKTLTPL
     VAVYFILYHL FVTLIVLSLF VAVILDNLEL DEDIKKLKQL KFREQSAEIK ETLPFRLRIF
     EKFPDSPQMT ILHRIPNDFM LPKVRESFMK HFVIELETED PSLVESCKRP MSECWESNVV
     FRKQKPVRIM NKTAKVRAAG SSLRKLAITH IINDSNNQRL MLGDSAMLPV VGTKGGGGLK
     SQGTITHSKP WRVDQKKFGS RSIRRSVRSG SIKLKQTYEH LMENGDIAAA PRANSGRARP
     HDLDIKLLQA KRQQAEMRRN QREEDLRENH PFFDTPLFLV PRESRFRKIC QKIVHARYDA
     RLKDPLTGKE RKVQYKSLHN FLGLVTYLDW VMIFATTLSC ISMMFETPTY RVMNHPTLQI
     AEYGFVIFMS LELALKILAD GLFFTPKAYI KDVAAALDVF IYVVSTSFLC WMPLNIPTSS
     AAQLLMILRC VRPLRIFTLV PHMRKVVYEL CRGFKEILLV STLLILLMFI FASYGVQLYG
     GRLARCNDPT IGRREDCVGV FMRRVFVTKM KLTPGVDESY PAMLVPRVWA NPRRFNFDNI
     GDAMLTLFEV LSFKGWLDVR DVLIKAVGPI HAIYIHIYIF LGCMIGLTLF VGVVIANYSE
     NKGTALLTVD QRRWCDLKKR LKIAQPLHLP PRPDGRKIRA FTYDITQHII FKRVIAVVVL
     INSMLLSITW IKGEVHTERL VIVSAVLTFV FVVEVVMKNI AFTPRGYWQS RRNRYDLLVT
     VAGVIWIILQ TILRNDLSYF FGFMVVILRF FTITGKHTTL KMLMLTVGVS VCKSFFIIFG
     MFLLVFFYAL AGTILFGTVK YGEGIGRRAN FGSPVTGVAM LFRIVTGEDW NKIMHDCMVQ
     PPYCTLGGNY WETDCGNFTA SLIYFCTFYV IITYIVLNLL VAIIMENFSL FYSNEEDALL
     SYADIRNFQN TWNIVDIHQR GVIPVRRVKF ILRLLKGRLE CDPQKDRLLF KYMCYELDKL
     HNGEDVTFHD VINMLSYRSV DIRKALQLEE LLAREEFEYL VEEEVAKMTI RTWLEGCLKK
     IRAQNASKQQ NSLIAGLRAT NEQPVMRPNV SQEDKAPSGV GVVDKSAIST ISGAVAGTCP
     PTSDAFSPTF SSTENEEKDG SSSAAVIVLP HAAHATDTAM GSQAAAAARH AIAVGKRAYA
     LNRSDSTGSS AGRKFLAPTS SDPQQRSTLS DKERLHISSQ QRKKNSMTTL PHSQLGQLGQ
     LGGKQRDGNK TTNFFAQLNS EIASQFHYPT INAATAAALH GDHQHVHHHG ALGSPSAMMS
     QLIGSSGKLL PFNNQANAVY EVHDWWQEQV LCTQTSDDEI
//
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