ID B4NCB6_DROWI Unreviewed; 4425 AA.
AC B4NCB6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Chitinase {ECO:0008006|Google:ProtNLM};
GN Name=Dwil\GK25829 {ECO:0000313|EMBL:EDW82475.2};
GN ORFNames=Dwil_GK25829 {ECO:0000313|EMBL:EDW82475.2};
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW82475.2, ECO:0000313|Proteomes:UP000007798};
RN [1] {ECO:0000313|EMBL:EDW82475.2, ECO:0000313|Proteomes:UP000007798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. Chitinase
CC class II subfamily. {ECO:0000256|ARBA:ARBA00009121}.
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DR EMBL; CH964239; EDW82475.2; -; Genomic_DNA.
DR RefSeq; XP_002071489.2; XM_002071453.2.
DR SMR; B4NCB6; -.
DR STRING; 7260.B4NCB6; -.
DR EnsemblMetazoa; FBtr0417844; FBpp0376005; FBgn0227788.
DR eggNOG; KOG2806; Eukaryota.
DR HOGENOM; CLU_000110_0_0_1; -.
DR InParanoid; B4NCB6; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR GO; GO:0004568; F:chitinase activity; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006032; P:chitin catabolic process; IEA:UniProt.
DR GO; GO:0018990; P:ecdysis, chitin-based cuticle; IEA:EnsemblMetazoa.
DR CDD; cd02872; GH18_chitolectin_chitotriosidase; 1.
DR Gene3D; 3.10.50.10; -; 1.
DR Gene3D; 2.170.140.10; Chitin binding domain; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR002557; Chitin-bd_dom.
DR InterPro; IPR036508; Chitin-bd_dom_sf.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR029070; Chitinase_insertion_sf.
DR InterPro; IPR001223; Glyco_hydro18_cat.
DR InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11177; CHITINASE; 1.
DR PANTHER; PTHR11177:SF400; CHITINASE 6, ISOFORM C; 1.
DR Pfam; PF01607; CBM_14; 2.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR SMART; SM00494; ChtBD2; 2.
DR SMART; SM00636; Glyco_18; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF54556; Chitinase insertion domain; 1.
DR SUPFAM; SSF57625; Invertebrate chitin-binding proteins; 2.
DR PROSITE; PS50940; CHIT_BIND_II; 2.
DR PROSITE; PS01095; GH18_1; 1.
DR PROSITE; PS51910; GH18_2; 1.
PE 3: Inferred from homology;
KW Chitin-binding {ECO:0000256|ARBA:ARBA00022669};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000489};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000489};
KW Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..4425
FT /note="Chitinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006458334"
FT DOMAIN 30..407
FT /note="GH18"
FT /evidence="ECO:0000259|PROSITE:PS51910"
FT DOMAIN 513..574
FT /note="Chitin-binding type-2"
FT /evidence="ECO:0000259|PROSITE:PS50940"
FT DOMAIN 4360..4425
FT /note="Chitin-binding type-2"
FT /evidence="ECO:0000259|PROSITE:PS50940"
FT REGION 415..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1647..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1870..1947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1959..1983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2002..2025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2072..2095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2208..2428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2459..2483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2528..2560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2613..2839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2888..3021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3034..3184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3210..3240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3415..3434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3448..3715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3762..3839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3853..3876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3960..3982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4215..4353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..646
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..665
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..937
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1084
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1391..1439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1483..1505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1512..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1647..1684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1687..1703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1704..1724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2002..2023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2072..2089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2208..2231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2240..2255
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2278..2295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2321..2337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2363..2384
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2404..2419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2459..2476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2613..2632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2648..2673
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2674..2817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2891..2920
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2928..2951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2963..2988
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2994..3021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3034..3051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3064..3093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3094..3110
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3138..3161
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3418..3434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3493..3512
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3550..3573
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3601..3653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3695..3715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3770..3785
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3786..3806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3812..3839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3960..3974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4259..4286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4312..4351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4425 AA; 488867 MW; A1655593BA4F0905 CRC64;
MLPFRRGAAW QTLFLLCALA YCINVVSSEG RVVCYYTNWS VYRPGTAKFN PQNINPYLCT
HLVYAFGGFT KDNQMKPFDK YQDIEQGGYA KFTGLKTYNK QLKTMIAIGG WNEASSRFSP
LVANPERRQQ FIKNILKFLR QNHFDGIDLD WEYPAHREGG KSRDRDNYAQ FVQELRAEFE
REAEKTGRTR LLLTMAVPAG IEYIDKGYDV PKLNKYLDWF NVLTYDFHSS HEPSVNHHAP
LYSLEEDSEY NYDAELNIDY SIKYYLKAGA DRDKLVLGIP TYGRSYTLIN EESTELGAPS
EGPGEQGDAT REKGYLAYYE ICQNLKDDPE WTIVQPNANV MGPYAYRRNQ WVGYDDEAIV
RKKAEYVVAQ GLGGIMFWAI DNDDFRGTCN GKPYPLIEAA KEAMIESLGL GINEVAKSSG
PQKPSRSRSR TDNGSTTRNR LNSKPAVGST RRPTSGSSGR RPAASSTPTT TTTTNAPPST
NIRLTEAEGS SLYIGGRAST TPPPPTTPDP GSDFKCEEEG FFQHPRDCKK YYWCLDSGPS
GLGIVAHQFT CPSGLYFNPA ADSCDFARNV PCKTKKSTTA APQTSPIPTT TVRTNRVTAA
PPAVARPIYP RTTTTTTSTT TTTTTRPSTI DDESEYEEEA DAAVDDADDD EARRQPVKSK
DAEEDPQVIK ELIDLIRKVG GVEQLEKHLL RNKDGSITLK ENSSIGNAGG AATTPSTISK
SLYDRVLSRQ GTLSSLTRKQ STFKVNSEPT TETTTTTASP DSNYSKYSSV LRGNSRQGPQ
NEGIEKLSEF DGFLKERKEY VTINRNRNAN KSGEELHAEA KEEEPETSTR RPYSPPTPSY
TSLRRTRPST VAPADPEEEP EQERKPIKSY STLGNTRGRT TEKPETPTTL ATGTESASSL
STNRYKYFER TRPTKSTTIS ASSDDTEEDD EEYDEEPQQQ QQQQNVTVLS KQSLTSTTNT
RKYASIGRSR TTTTATPETT TTTTTRTTTT FTETAKANNS NNVLSNNIIQ TAEEAAPPQP
PSTTHHPETL TILNEITEPI ESTSITNLTL STTNQTPTTT YTHIPTTTPT PTPTPTPTPT
PTPTPNIETT TTAIESQTSS IDSLNLTDEI ELTTQLPVSL LNNANPTPIP ILKITTTTTT
GTTTTADELA TTTTATATAT STTSNDINDV NNDHIDSDEV TQSPNPNQTK YLTISQRRKN
AEAVNDASPN SLSSSNIPNV NSFRTTYSGR RQPQTTPTTT TTNPDLNLND VGNRISSPRP
FGYPRRRTRP TTTTTTTTPT STTIQHSTDN DNINEAVENT VKTRLSQVDR SKVSASHSHD
TTQTNTNTTT TTTTNNKNNH VDVAGNGGNS LRHEVVSSSL STDSNRTTTT DWRTVRRPSR
RPAVNPNTLD TENKDSRRYA GKRLDTDDEN PEIQVDSSTK YRSRRLNSAE QETEAANEAK
NKTETAPLSA AGLQQSSDST NEDENIAAEI IDDEPPAIER GKTKAPSQQT SDDSNTATEQ
EDSPLDTTLV PDVLENYTTT TTTTTEEPSS SSSTETQESS TESKEGVQVI TEASLINEEN
SALGASTETT STEGPAKATT EATTRRSFLR NKFTTTSTAS STSTTTEENV ETTTSTPSRR
RVIVRGKYRP SKEGDLSSLL AADANKRVNS RTSTNNGNIS SSSLSSSSST STTTTTTTTT
PVPAASEDDD AADKVKKTFV GSQRENKKLN SRTPLNGQHN RTSTKVESLG NGITRTRTTN
VRTIDAGRKV VKKIHTKIVE EKPAEYEYVY DEVSQPIAST TTPRAITRNR GSVKFQSNDL
SSLLALDFAS RGSRNKQSEN KPTVTKTRRR LLKRPKETIE REEVEEYEYE TDDEVNGDSL
LTTTTAKTIE RRTRPTRIAT TPTTRTTTRA TTTETNPEVT TRRIVHTFKR PTTSTTTTTT
TTTTTEEPST LSTSSSSAIE EDTTEDQLAA AKQRFVSRLS ARKTTSTSTT TSTTTETPPS
TTLADDLSEL KQKYISALNR LQTNNDVEAN ESTTTTPSSE QDDLSLPIYH RRKYYQYVKD
SPITYIDKSP APPDIESVTV NIRQQIHDVF NVSENSESTG SNSVDNQEET SSELEQRLAM
EQAREINSEL GHFLLKTPGS TLQGIRKGKT FKTTLQEPSS TVNETSRIVQ LSVLGDERQE
EDARSLRTYS KLNRTRLTLA AKVEVAEDEN ESSTKRIYSI PQRIPNRSTV SISSTTARPT
SRRTYAGINR QRPQETKEES LDDEELQEIN ENADGEEDKE NVLATTTPST FRRRPFTPRG
QLVKDESEKE TTTKSAPRRT YAGISRKPAL GIPSNTNTED DESADVEKDK QNETKTTAKP
VPRRTYIGLN RQRPLETVSN TTTEEPLEDE ELQAINENTE GEEDKENDLV TTTPAANKPR
PFTRRGQLVK EESETETATK TAPRRTYAGI NRKPALGIAS NNTTDEPIED KDLQAINDSV
NGEEDKQTET TKRTTAKPAP RRTYIGLNRQ RPLETATDTT TTVQTLENAE LQAVNGEEDK
ASILVSTTPS ANRRRPFTSR SQLVKEESEN TKTTTVKPTS RRTYAGINRK PALGTATEEP
LEDEELQAIN ENTDDEEDNE NVLLTTTPSA SRNQLVENED ETTKTTTTAK PTYAEVDRKP
PQEAVGTTEE TLEDEELEAI NEITDDDENT DEESVIVTTT PSTSTAKPSP TSRRQLTIRR
RLNTSSTTTT TRTTIPDGQE ENENSTSTST NASPTSRRQL LIRRRTTTVK PSPDNEIEIT
TTTESASRSQ LLTRGRGRFN SSTNAEVTTR RSYANLSRTR NRFTASRPTT TPTPESAIES
DFDAKPDAEN RGAAAAREGL FATNRHRALL DDRDRTSIRR RTTVAPVRLN SSTRRNLVAL
NRNLYKKVEE QEEYDEDEEK EEEHDQQNEE DEEQDEQEDD QEQEKPRIQT TSRLSQLLAS
RQQQKQRQLH TQVQKQTEEN DIDIENGEGD GDGNGNGDDI EGEVDEDDEH SQNNTNTNTK
TNNNNNNGRS NVTNLSTNRS NSTVANYLIN RFKFNNRNNQ NQQNNNTKTV SDEANEEIDD
IENGRVSSSL NDLGNNVNSK RRFQNRYQLS RTPTSATPPP PPPPPTTTAR TSSTPTPSRL
PFGSRKRVQV TEINHTQSDD DENDEVEAEQ DDDDDDDYDS DEKSTTATTT TKTPTAPTPR
RIRVLKYRRP LQINNSNNIT SLNSTTTLNS ATNINQDTST TTTTTSNTTT TNNNNNNTTV
ISPTKRFRKI VRKLRPVETS SEKINSNDEE KLGETTLNST ATTTTTTTRK PFVPKRSRFN
AGQDEDSNDL LSIRNRLKEQ QARGEPLDGV INSRLNGQAR DDLAGDAGNA SDLQRLRNKV
RIEQARGDGD DGVINDRLKK LLSEKSQNVN TTVDVASPSS PAKRPVFRRK LVAKRPVNSP
VQGQSLTTKA PSLIFNSTRP TRKFVRRKNG RFDPFNSSVK NTGEGFVRSD PRGARLPGTQ
RFKQQQRPKN GEGEEDDDEE DGDYDEAEPE EEPPQVVAIK RPFALSKPIK SQQSQSEISK
SKVKEEKQES GEEDDDDDDD DEDDDDDADG NEVEETTEAH AKPAYKPKDN RIPPGSRPSY
TPTGPGTTGS GNVPYNPRNR PYSSSTGSRF GTSGSSSSST SSSNGSSSTK RPRVINRPPG
VATPNLTLRP VANDYERTTP LTPLKPAPFI PSNTRSYERK YTGPSTTETS ETANENSLIE
DLNIDALNAR NKKIFKINSK KHTTLKPKVV VSQGQDNSLE QGFLTTTPQS APQPPQPPPP
RSPNTPSTST STQEQQSNNT ENTELDSVTE TDTESTDNAN ASSIPQDDGS WTTPQPPPAT
TLLHVFTLLD SDGDDSQLKP TRRPSLAANL PTKTTEVEPK HKLIEINRIV EINSKQAKAA
QRKSKANQDF GTLRVESLPH VEQLGEISVV KYVHLVDGSA IQINDGHSTV ADYTPTEPTV
YYSSSSTPVR NSLPQQEEAD LDADRSGKSL LPEVLIGALE TSTISLEGLF DSARKGKQLS
SNQILGEIET TSSSSDTTTT TATTTTPLAN TYLRQTTTAN VSRRPVLSVR KRIINTPRLA
TTTITPAAAN KLKSTGESAT LLPATSHSNN NDIISQHKFQ PASFALRRQF QTRRLTTLAP
STIADDSATE VPHTQNPLFK RRLTLTSTIS APRTTTVSAT SETTTNLYAN DDDDDQIAKS
SIHTSRFNQI LSEHGHSRED FDPPSSSSSS RPPTPPTKQP TEIGALSQGL RRQLIPRPRR
PHSTTQTPAT TAASNLDYSS PPLSRRQQSR RRPHKYIEVY SRPPSKPELA SATLSRRRSA
SVDSDYYDNG QQQLTPGQRQ RQKNSQPSSD PKVIVHGRGV IECLAQGNFP HPLNCRKFIS
CAKFEETGGI VGWEYTCPKG LTYDGVDGMC TPWSTSSGVE GGCRA
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