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Database: UniProt
Entry: B4NLF0_DROWI
LinkDB: B4NLF0_DROWI
Original site: B4NLF0_DROWI 
ID   B4NLF0_DROWI            Unreviewed;      1296 AA.
AC   B4NLF0;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   05-JUL-2017, entry version 63.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW84353.1};
GN   Name=Dwil\GK14093 {ECO:0000313|EMBL:EDW84353.1};
GN   ORFNames=Dwil_GK14093 {ECO:0000313|EMBL:EDW84353.1}, GK14093
GN   {ECO:0000313|FlyBase:FBgn0216099};
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW84353.1, ECO:0000313|Proteomes:UP000007798};
RN   [1] {ECO:0000313|EMBL:EDW84353.1, ECO:0000313|Proteomes:UP000007798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
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DR   EMBL; CH964272; EDW84353.1; -; Genomic_DNA.
DR   RefSeq; XP_002073367.1; XM_002073331.2.
DR   STRING; 7260.FBpp0243236; -.
DR   EnsemblMetazoa; FBtr0244744; FBpp0243236; FBgn0216099.
DR   GeneID; 6651153; -.
DR   KEGG; dwi:Dwil_GK14093; -.
DR   FlyBase; FBgn0216099; Dwil\GK14093.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   InParanoid; B4NLF0; -.
DR   KO; K04967; -.
DR   OMA; GRMISGW; -.
DR   OrthoDB; EOG091G029I; -.
DR   PhylomeDB; B4NLF0; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0034703; C:cation channel complex; IEA:EnsemblMetazoa.
DR   GO; GO:0016027; C:inaD signaling complex; IEA:EnsemblMetazoa.
DR   GO; GO:0035997; C:rhabdomere microvillus membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005262; F:calcium channel activity; IEA:EnsemblMetazoa.
DR   GO; GO:0010461; F:light-activated ion channel activity; IEA:EnsemblMetazoa.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblMetazoa.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblMetazoa.
DR   GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblMetazoa.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:EnsemblMetazoa.
DR   GO; GO:0008377; P:light-induced release of internally sequestered calcium ion; IEA:EnsemblMetazoa.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:EnsemblMetazoa.
DR   GO; GO:0008355; P:olfactory learning; IEA:EnsemblMetazoa.
DR   GO; GO:0030845; P:phospholipase C-inhibiting G-protein coupled receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; IEA:EnsemblMetazoa.
DR   GO; GO:0008104; P:protein localization; IEA:EnsemblMetazoa.
DR   GO; GO:0046154; P:rhodopsin metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:EnsemblMetazoa.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00844120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007798};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007798};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    378    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    437       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    461    481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    551    573       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    612    630       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    637    662       Helical. {ECO:0000256|SAM:Phobius}.
FT   REPEAT      144    176       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      144    176       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
SQ   SEQUENCE   1296 AA;  145098 MW;  04B2068A2CD02EFE CRC64;
     MTTNTETDAE KAAGSRLDYD LMMAEEYILS DVEKNFILSC ERGDLQGVKK ILEEYGTESD
     KFNINCTDPM NRSALISAIE NENFDLMVLL LENNIEVGDA LLHAISEEYV EAVEELLQWE
     ESHHKEGQPY SWEAVDRSKS TFTMDITPLI LAAHRNNYEI LKILLDRGAT LPMPHDVKCG
     CDECVTSQTT DSLRHSQSRI NAYRALAASS LIALSSRDPV LTAFQLSWEL KRLQAMESEF
     RAEYTEMRQM VQDFVTALLD HARTSMELEV MLNFNHEPSH EIWCPGQRQT LERLKLAIRY
     KQKTFVAHPN VQQLLAAIWY EGLPGFRRKQ SSQQLMDVIK LGCSFPIYSL KYILAPDSDG
     AKFMRKPFVK FITHSCSYMF FLMLLGAASL RVVQITFELL AFPWMLTMLE DWRKHERGSL
     PGPIELAIIM YIFALIFEEL KSLYSDGLFE YIMDLWNIVD YISNMFYVTW ILCRATAWVI
     VHRDLWFRGI DPYFPREHWH PFDPMLLSEG AFAAGMVFSY LKLVHIFSIN PHLGPLQVSL
     GRMIIDIIKF FFIYTLVLFA FGCGLNQLLW YYAELEKNKC YHLHPDVADF DDQEKACTIW
     RRFSNLFETS QSLFWASFGL VDLVSFDLAG IKSFTRFWAL LMFGSYSVIN IIVLLNMLIA
     MMSNSYQIIS ERADTEWKFA RSQLWMSYFE DGGTIPPPFN LCPNMKMLRK TLGRKRPSRT
     KSFMRKSMDR AQVLHDKVMK LLVRRYVTAE QRRRDDYGIT EDDIIEVRQD ISSLRFELLE
     IFTNNSWDVP DIEKKTHAAA RTTKGKVMER RILKDFQIGF VENLKQEMNE GDGRDIFSSL
     AKVIGRKKTQ KGDKDWNAIA RKNTFTADPI GSKRSSMQRH SQRSLRRKII EQANEGLLMN
     QNQLIEFNPN LGDVTRATRV AYVKFMRKKM AADEVSMGDD EERPPGEEND RKPDDKKLDA
     SGSKKSMSSA GAAGGGASFM AAAALRASVK NVDETKKPGE GGKDNAKPGA DKKPDDNKKP
     TDVKKPNEDK DKEKDKKSTS DSKSEVKPGA AAPPVAGKSS DQKPPPAAGA PKPTSAKEQQ
     KPGDTNGKPN APAPPAKPPS DAKPTAPKPG EVSKPEAATK KEESAKAESA KPSTATATGG
     AAKSAAPSAP AEAKPDTKTT TTTTTAGAGA TKDATKAANE TSSQTASQAA KPDDKKDQKD
     QKDQKADQKP DDKKGTNGKP GDAKTGETKP DATKQPDSAQ KPTDDKDKKP GDDKDKKPGA
     APAPLKPAIK VGQSSAAAGG ERGKSTVTGR MISGWL
//
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