ID B4NZI7_DROYA Unreviewed; 2122 AA.
AC B4NZI7;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=Myosin-VIIa {ECO:0008006|Google:ProtNLM};
GN Name=Dyak\GE14590 {ECO:0000313|EMBL:EDW87736.2};
GN ORFNames=Dyak_GE14590 {ECO:0000313|EMBL:EDW87736.2};
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245 {ECO:0000313|EMBL:EDW87736.2, ECO:0000313|Proteomes:UP000002282};
RN [1] {ECO:0000313|EMBL:EDW87736.2, ECO:0000313|Proteomes:UP000002282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01
RC {ECO:0000313|Proteomes:UP000002282};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDW87736.2, ECO:0000313|Proteomes:UP000002282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01
RC {ECO:0000313|Proteomes:UP000002282};
RX PubMed=17550304; DOI=10.1371/journal.pbio.0050152;
RA Ranz J.M., Maurin D., Chan Y.S., von Grotthuss M., Hillier L.W., Roote J.,
RA Ashburner M., Bergman C.M.;
RT "Principles of genome evolution in the Drosophila melanogaster species
RT group.";
RL PLoS Biol. 5:E152-E152(2007).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; CM000157; EDW87736.2; -; Genomic_DNA.
DR RefSeq; XP_002088024.2; XM_002087988.2.
DR SMR; B4NZI7; -.
DR EnsemblMetazoa; FBtr0393476; FBpp0352855; FBgn0232186.
DR GeneID; 6526926; -.
DR KEGG; dya:Dyak_GE14590; -.
DR eggNOG; KOG4229; Eukaryota.
DR HOGENOM; CLU_000192_14_1_1; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000002282; Chromosome 2L.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IEA:EnsemblMetazoa.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692:SF33; MYOSIN; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 66..737
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1031..1239
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1244..1551
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1674..1819
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1825..2122
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 615..637
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 903..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 830..894
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 159..166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2122 AA; 242974 MW; AA01BE8108F504B6 CRC64;
MSEFVRQHGE YVWVKPQNTT SEFAVPFGAR IVRTEKTQTL VCDDRNKQFW VPAGDVLKAM
HITSQEDVED MITLGDLQEY TILRNLQNRY AKQLIYTYTG SMLVAINPYQ ILPIYTNREI
QLYRNKSLAE LPPHIFAISD NAFQRLQRLK ENQCVVISGE SGAGKTESTK LILQYLAAIS
GKHSWIEQQI IEANPIMEAF GNAKTVRNDN SSRFGKYIEI RFTPQGAIQG ARIQQYLLEK
SRIVFQSRDE RNYHIFYCML AGLSGPERER LKLQEQSPSQ YHYLAQGGCF TLPGRGDAKD
FADIRAAMKV LSFKPEEVWS ILSLLAAILH LGNLRFTATE VANLATAEID DTPNLQRVAQ
LLGIPISALN AALTQRTIFV HGEHVTTSLS KEAAIEGRDA FVKSLYDGIF VRIVRRINET
INKQVDQPMN SIGVLDIFGF ENFDNNSFEQ LCINYANENL QQFFVGHIFK MEQDGYQNEH
INWQHIEFQD NQQILDLIGM KPMNLMSLID EESKFPKGTD QTLLEKLHVQ HGNRSIYVKG
KTTQTSLFGI RHYAGVVMYN PLGFLEKNRD SFSGDLRTLV QRSANKFLVD IFPHEMPMDT
AKKQPTLCVK FRNSLDMLMR TLSQAHPYFI RCIKPNEYKE PKNFDKELCV RQLRYSGMME
TARIRRAGYP IRHAYRAFVE RYRLLVPPVG PLEKCDCRKV ARQICEVALP ADSDRQYGKT
KLFLRDEDDA RLELQRSQVM LKSIVTIQRG IRRVLFRRYL KRYREAIITV QRYWRGRLQR
RKYQVMRQGF HRLGACIAAQ QLTTKFTMVR CRTIKLQALS RGYLVRKDFQ DKLLERRKQQ
QLKKEELLKL AKLKEAEELL RLQQLKEQQE KEQREQQEKR LQEEQRLKAE AAARNALAMA
AVQQKRRSRP LKPEAPKAPT LQARNSLPPP PTTLIVAAPL PTRPASAANR INTIPESPGT
TIDVESSKQM VDDVFRFLND EPDAALRKLN NLSSGDTIRL PKSVPNNIDT SDFSYLKYAA
TYFGGGATAQ HERKPLKESL LKHEQPLDEM ASKAIWLTIL RFMGDLPDVV SSPSLHSSNN
ENLMSDLACL LNTPDSYKPR LFVRQSQRRI PKPLANGEKE AQEFYQHWLS IPTSHLEKLH
FIIGHGIIKN SLRDEILAQI CKQLYLNPSR SSYSRGWLLL SLCLSCFPPS QEFEPHLRSF
MKQGTAQLQA TPSLQRLERT LVNGPRCQPP SLFELHAIRG RQPLKLDIHL MDGQQRRLQV
DAASTAREAV HQLCQGMGLT DTFGFGLVMS LNGKLMPLGA GQEHVLDAIS ECEQRQLDAP
WKLYLRKEMF ATWYDPSVDP KATQLIYKQI LNGLKCGEYR CRSEKDIAMV CALACFVEHG
PGDILRLKPS EITAFVPSDL LAPGERAIEN WSRLIAVTYE KSSYVKEEQK DLLLEAQKRA
KEDICLFAHL SWPMRHSRLF EVVRKEGPKL QSDDLMLGIN STGLFLIDET EQVLASCCFS
ELLKVHMESN DKLHIMTFQH VNFVLQCSAA QDANEVINYM LDNLRQRSSY GVALDQVVQG
DLEDCLVLSP GDLIEFEAGV TGAQLMAGNA QDCYRGCVNG QWGQFAAGNV RVLATLSKPS
EKLQDILREG RFAEPPKPTP RATYSRRRQH NISQLAESQF REPLDSDKAS LSTFSPEPLK
APLLKAVAKV PPLFQQALVM HHHILKYMGD IARSNLPVNT DLIFQPALQH PLLCDELYCQ
LMKQLSDNPS SESEKRGWDL LYLVTGLVAP SVLVMRELII LLRMRADALA DACLKRLKRS
LAQGQRKQAP HLIEVEGIQQ RCLHIYHKIY FPDDTVEAFE IESHTRGAEL IADIAQRLEL
KSPVGYSIFL KTGDRVYAMP EEEFVFDFIT QLIYWLRQQK TIRSISDGHY QLHFMRKLWL
NNHPGEDLNG DVIFSYPQEL HKYLKGYYPI DCEQASRLAV LVYSADHEVS LQRLPEVLPR
LVPEDLIPLR TVAEWRQQIL PKIHRDHLTE DHAKLLFLQE LAHFACFGST FFVVKQQNDD
ALPETLLIAI NSTGFHLLDP PTKEILRSYE YSQLGIWSSG KNHFHIRFGN MIGAAKLLCS
TTQGYKMDDL LASYVRYFNE HE
//
