ID B4QYR5_DROSI Unreviewed; 2901 AA.
AC B4QYR5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=GD18032 {ECO:0000313|EMBL:EDX14734.1};
GN Name=Dsim\GD18032 {ECO:0000313|EMBL:EDX14734.1};
GN ORFNames=Dsim_GD18032 {ECO:0000313|EMBL:EDX14734.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX14734.1, ECO:0000313|Proteomes:UP000000304};
RN [1] {ECO:0000313|EMBL:EDX14734.1, ECO:0000313|Proteomes:UP000000304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mosaic {ECO:0000313|Proteomes:UP000000304};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CM000364; EDX14734.1; -; Genomic_DNA.
DR SMR; B4QYR5; -.
DR STRING; 7240.B4QYR5; -.
DR HOGENOM; CLU_000391_0_0_1; -.
DR OMA; IVMLVQD; -.
DR PhylomeDB; B4QYR5; -.
DR Proteomes; UP000000304; Chromosome 3r.
DR GO; GO:0005604; C:basement membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:EnsemblMetazoa.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:EnsemblMetazoa.
DR CDD; cd00096; Ig; 1.
DR CDD; cd00109; Kunitz-type; 8.
DR CDD; cd22639; Kunitz_papilin_lacunin-like; 1.
DR CDD; cd22637; Kunitz_papilin_mig6-like; 3.
DR CDD; cd00199; WAP; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 12.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR008197; WAP_dom.
DR PANTHER; PTHR45938; ACP24A4-RELATED; 1.
DR PANTHER; PTHR45938:SF11; PAPILIN; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00014; Kunitz_BPTI; 12.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 5.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00131; KU; 12.
DR SMART; SM00209; TSP1; 7.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57362; BPTI-like; 12.
DR SUPFAM; SSF57256; Elafin-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 7.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 7.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 12.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
DR PROSITE; PS51390; WAP; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000304};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..2901
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002824680"
FT DOMAIN 1614..1664
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1673..1723
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1732..1782
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1792..1842
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1851..1901
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 1924..1974
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2003..2053
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2073..2123
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2130..2180
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2197..2247
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2256..2306
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2321..2374
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 2455..2501
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 2526..2610
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2620..2700
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2752..2843
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2850..2889
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 43..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1975..2007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..1214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1978..2003
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 69..105
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 73..110
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 84..95
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 2901 AA; 313620 MW; 6B7BC9C559EF4FDF CRC64;
MDLSRRLCST ALVAFIVLAG IHDSQSRFPG LRQKRQYGAN MYLPESSVTP GGEGNDPDEW
TPWSSPSDCS RTCGGGVSYQ TRECLRRDDR GEAVCSGGSR RYFSCNTQDC PEEESDFRAQ
QCSRFDRQQF DGVYYEWVPY TNAPNPCELN CMPKGERFYY RQREKVVDGT RCNDKDLDVC
VNGECMPVGC DMMLGSDAKE DKCRKCGGDG STCKTIRNTI TTKDLAPGYN DLLLLPEGAT
NIRIEETVPS SNYLACRNHS GHYYLNGDWR IDFPRPMFFA NSWWNYQRKP MGFAAPDQLT
CSGPISESLF IVMLVQEKNI SLDYEYSIPE SLSHSQQDTH TWTHHQFNAC SASCGGGTQS
RKVTCNNRIT LAEVNPSLCD QKSKPVEEQA CGTEPCAPHW VEGEWSKCSK GCGSDGFQNR
SITCERISSS GEHTVEEDAV CLKEVGNKPA TKQECNRDVK NCPKYHLGPW TPCDKLCGDG
KQTRKVTCFI EENGHKRVLP EEDCVEEKPE TEKSCLLTPC EGVDWIISQW SGCNACGQNT
ETRTAICGNK EGKVYPEEFC EPEVPTLSRP CKSPKCEAQW FSSEWSKCSA PCGKGVKSRI
VICGEFDGKT VTPADDDSKC NKETKPESEQ DCEGEEKVCP GQWFTGLWGE CSKLCDGGER
VREVLCLSNG TKSVNCDEEK VEPLSETCNS EACIEDEVFP FISDDEPIED DEEDCDEDGI
ELISDGLSDD EKSEDVIDLE GTAKTETTPE DEELMQSDSP TPFDEFESTG TTFEGSGYDS
ESTTDSGIST EGSGDDEETS EASTDLPSST DSESTSSESS SSDSSSSISS DATSEAPASS
VSDSSDSTDA STETTGISVD STDVSSSTEA SASESTDVSG ASDSTDSTNA SDSTSESSTE
ASSSTDDSTD SSDNSSNVSE SSTEASSSSV SDSSDSTDGS TDGASSTTEN SSDSTSDAPS
DSTASSDSTD STSDQTTDTT PESSTDSTES STLDASSTTD ASSTIESSTE SSTDGSSSTS
DSESTETTGL SSDGSTGTTD ATTATSDSSD STTDGSTDQS TDGSSDASTD GSTEGASEDT
TLSTESSGST ESTDANASDG STTEGSTVDD LSSSTSSDVT SDSTITDSSS STEVSGSTDS
SSSTDGSSTD ASSTEASSTD VTESTDSTVS GGTSDTTESG PTEESTTEGS TESTTEGSTE
STQSTDLDST TSDIWSTSDK DEESESSTPY SFDSEVTKSK PRKCKPKKSM CAASKYGCCP
NGKSTPKGPF DEGCPIAKTC ADTKYGCCLD GVSPAKGKNN KGCPKSQWAE TLFGCCPDKF
TAADGENNEG CPETTTVPPT TTTEESQPET TTEIEGSGQD STTLEPDTKK SCSFSEFGCC
PDAETSAKGP DFEGCGVASP GAKGCAESEN GCCPDGQTPA SGPNGEGCSG CTRERFGCCP
DSQTPAHGPN KEGCCLDTEF GCCPDNILAA RGPNNEGCEC HYTPYGCCPD NKSAATGYNQ
EGCACETTQY GCCPDKITAA KGPKHEGCPC EATQFGCCPD GLTFAKGPHH HGCHCTQTEF
KCCDDEKTPA KGPNGEGCTC VESKFGCCPD GVTKATDEKF GGCENVQEPP QKACGLPKET
GTCNNYSVKY YFDTSYGGCA RFWYGGCDGN DNRFESEAEC KDTCQEYTGK HVCLLPKSAG
PCTGFTKKWY FDVDRNRCEE FQYGGCYGTN NRFDSLEQCQ GTCAASENLP TCEQPVESGP
CAGNFERWYY DNETDICRPF TYGGCKGNKN NYPTEHACNY NCRQPGVLKD RCALPKQTGD
CSEKLAKWHF SENEKRCVPF YYTGCGGNKN NFPTLESCED HCPRQVAKDI CEIPAEVGEC
ANYVTSWYYD TQDQACRQFY YGGCGGNENR FSTEESCLAR CDRKPEPTTT TPAPRQQASS
QAVCDEEPAP GECSNWVLKW HFDRKVGACR QFYYGNCGGN GNRFETEHDC QQRCLSQEPP
APTPPRAPAP TRQPDPAPTV PQCSQPADPG QCDKWALHWN YNETEGRCQS FYYGGCGGND
NRFATEEECS ARCSVNIDTR ISADPVEHDT SKCFLAFESG NCYDNVTRWF YNSAEGLCDE
FVYTGCGGNA NNYATEEECQ NECNDAQTTC ALPPVRGRCS ELSRRWYFDE RSGECHEFEF
TGCRGNRNNF VSQSDCLNFC IGLTVVEEPS APTYSVCAEP PEAGECDNRT TAWFYDSENM
ACTAFTYTGC GGNGNRFETR DQCERQCGEF KGVDVCNEPV TTGPCTDWQT KYYFNTASQA
CEPFTYGGCD GTGNRFSDLF ECQTVCLAGR EPRVGSAKEI CMLPVATGRC NGPSVHERRW
YYDDAAGNCV SFIYAGCSGN QNNFRSFEAC TNQCRPEPNK QDNEIGQNPC DTFDAECQEL
RCPYGVRRVA ARSQPECTQC ICENPCEGYS CPEGQQCAID VASSDDRQFA PVCRDIYKPG
ECPALSANAS GCARECYTDA DCRGDNKCCS DGCGQLCVHP ARPTQPPRTQ APVVSYPGDA
RAALEPKEAH ELDVQTAIGG IAVLRCFATG NPAPNITWSL KNLVINTNKG RYVLTANGDL
TIVQVRQTDD GTYVCVASNG LGEPVRREVA LQVTEPVSQP AYIYGDKNVT QIVELNRPAV
IRCSAGGFPE PHVSWWRNGQ MFGLKNNLMA RDYSLVFNSI QLSDLGLYTC EVYNQRRPVS
LRVTLKAVGP VRPLSPEEEQ YMQYVLNPAT RPVTQRPSYP YRPTRPAYVP EPTVNVHAVL
ALEPKNSYTP GSTIVMSCSV QGYPEPNVTW TKDDVPLYNN ERVQITYQPH RLVLSDVTPA
DSGKYTCRAS NAYTYANSEA NVSIQSVVPV SPECVDNPYF ANCKLIVQGR YCSNPYYTKF
CCRSCTLAGQ VATPPLHPNA V
//
