ID B4RB46_PHEZH Unreviewed; 286 AA.
AC B4RB46;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:ACG78097.1};
GN OrderedLocusNames=PHZ_c1686 {ECO:0000313|EMBL:ACG78097.1};
OS Phenylobacterium zucineum (strain HLK1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Phenylobacterium.
OX NCBI_TaxID=450851 {ECO:0000313|EMBL:ACG78097.1, ECO:0000313|Proteomes:UP000001868};
RN [1] {ECO:0000313|EMBL:ACG78097.1, ECO:0000313|Proteomes:UP000001868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLK1 {ECO:0000313|EMBL:ACG78097.1,
RC ECO:0000313|Proteomes:UP000001868};
RX PubMed=18700039; DOI=10.1186/1471-2164-9-386;
RA Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.;
RT "Complete genome of Phenylobacterium zucineum - a novel facultative
RT intracellular bacterium isolated from human erythroleukemia cell line
RT K562.";
RL BMC Genomics 9:386-386(2008).
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DR EMBL; CP000747; ACG78097.1; -; Genomic_DNA.
DR RefSeq; WP_012522239.1; NC_011144.1.
DR AlphaFoldDB; B4RB46; -.
DR STRING; 450851.PHZ_c1686; -.
DR KEGG; pzu:PHZ_c1686; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_5; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000001868; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001868}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 162..280
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 168
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 286 AA; 30005 MW; B953D67B67F276FA CRC64;
MKVAFAGLGV MGFPMAGHLA RAGHEVSVYN RSPDKARRWV EAHGGRMGET AAEAAAGAQV
LALCVGNDDD VRQVVAQALP ALADGAVIVD HTTTSAVVAR EMAALAAQSG RAFVDAPVSG
GQAGAEAGQL TIMCGGDEAA FAKVEPVIAA YAKAIRRMGG PGAGQLTKMV NQICIAGVVQ
GLAEGLHFAR RAGLDPQAVY EAISKGAAQS WQMDNRWKTM SEGRFDFGFA VDWMRKDLGL
LLDEATRNGA TLEMTAMVDR FYAEVQALGG ARWDTSSLVA RLEKPE
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