ID   B4REB5_PHEZH            Unreviewed;       496 AA.
AC   B4REB5;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   OrderedLocusNames=PHZ_c0443 {ECO:0000313|EMBL:ACG76857.1};
OS   Phenylobacterium zucineum (strain HLK1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Phenylobacterium.
OX   NCBI_TaxID=450851 {ECO:0000313|EMBL:ACG76857.1, ECO:0000313|Proteomes:UP000001868};
RN   [1] {ECO:0000313|EMBL:ACG76857.1, ECO:0000313|Proteomes:UP000001868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HLK1 {ECO:0000313|EMBL:ACG76857.1,
RC   ECO:0000313|Proteomes:UP000001868};
RX   PubMed=18700039; DOI=10.1186/1471-2164-9-386;
RA   Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.;
RT   "Complete genome of Phenylobacterium zucineum - a novel facultative
RT   intracellular bacterium isolated from human erythroleukemia cell line
RT   K562.";
RL   BMC Genomics 9:386-386(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; CP000747; ACG76857.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4REB5; -.
DR   STRING; 450851.PHZ_c0443; -.
DR   KEGG; pzu:PHZ_c0443; -.
DR   eggNOG; COG4191; Bacteria.
DR   HOGENOM; CLU_040271_0_0_5; -.
DR   Proteomes; UP000001868; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00075; HATPase; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   PANTHER; PTHR44936:SF9; SENSOR HISTIDINE KINASE GLNK; 1.
DR   PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACG76857.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001868};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        30..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        182..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          203..258
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          272..483
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   COILED          232..259
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   496 AA;  53339 MW;  BAB8A39438E652F5 CRC64;
     MMADAPAPNE PPARDRRRRL FWPGGLSARL LVLTVLFAAL GGLIAIPPAL AAFERQWLLD
     RVRAAELASL APEVAPDRVV SEQLKTELLR GAGVEIVAIS VDGVRSLVFA GARPAEAPYL
     VDLRPRAAAG LGVFAPFRTL FGPEGRRVRV VAEPRFREAE FIEFVATDTE LKRALAGYLW
     RLIGIVVFVS TLAGVLVFVA LNLFLVRPMQ RITHAMERFR ADPDDPAARV ELSGRRDEIG
     RAEAELDRMQ ADLRVALNSR ARLAALGEAV AKINHDLKNM LTSAQIASER LAALQDPKVS
     QALPRLERAL DRAVKLASDV LAYGKTQEAA PEPRRVALAE AVAEAALEAR LSDEGVRLVS
     KVERSAQVTA DPDQLHRILA NLFRNAREAI EHQEGRTAPG RVEVSLAAAN GGCLVRVADN
     GPGIPGRVRE RLFQPFAGSG RPDGAGLGLA IARELALGHG GDLSLAATGP EGSVFELRLP
     GAPTKAPARR RTKSPA
//