ID ISCS_NEIG2 Reviewed; 404 AA.
AC B4RMB8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 01-MAY-2013, entry version 35.
DE RecName: Full=Cysteine desulfurase;
DE EC=2.8.1.7;
GN Name=iscS; OrderedLocusNames=NGK_1278;
OS Neisseria gonorrhoeae (strain NCCP11945).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC Neisseriaceae; Neisseria.
OX NCBI_TaxID=521006;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCCP11945;
RX PubMed=18586945; DOI=10.1128/JB.00566-08;
RA Chung G.T., Yoo J.S., Oh H.B., Lee Y.S., Cha S.H., Kim S.J., Yoo C.K.;
RT "Complete genome sequence of Neisseria gonorrhoeae NCCP11945.";
RL J. Bacteriol. 190:6035-6036(2008).
CC -!- FUNCTION: Catalyzes the removal of elemental sulfur from cysteine
CC to produce alanine (By similarity).
CC -!- CATALYTIC ACTIVITY: L-cysteine + acceptor = L-alanine + S-
CC sulfanyl-acceptor.
CC -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. NifS/IscS subfamily.
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DR EMBL; CP001050; ACF29954.1; -; Genomic_DNA.
DR RefSeq; YP_002001903.1; NC_011035.1.
DR ProteinModelPortal; B4RMB8; -.
DR SMR; B4RMB8; 4-391.
DR STRING; 521006.NGK_1278; -.
DR EnsemblBacteria; ACF29954; ACF29954; NGK_1278.
DR GeneID; 6447364; -.
DR KEGG; ngk:NGK_1278; -.
DR PATRIC; 20341005; VBINeiGon87511_1368.
DR eggNOG; COG1104; -.
DR HOGENOM; HOG000017510; -.
DR KO; K04487; -.
DR OMA; LWEMFKQ; -.
DR ProtClustDB; PRK14012; -.
DR BioCyc; NGON521006:GJ73-1302-MONOMER; -.
DR GO; GO:0031071; F:cysteine desulfurase activity; IEA:HAMAP.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006534; P:cysteine metabolic process; IEA:InterPro.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR HAMAP; MF_00331; Cys_desulf_aminotr_5; 1; -.
DR InterPro; IPR000192; Aminotrans_V/Cys_dSase.
DR InterPro; IPR020578; Aminotrans_V_PyrdxlP_BS.
DR InterPro; IPR010240; Cys_deSase.
DR InterPro; IPR016454; Cysteine_dSase_NifS.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_major_sub2.
DR Pfam; PF00266; Aminotran_5; 1.
DR PIRSF; PIRSF005572; NifS; 1.
DR SUPFAM; SSF53383; PyrdxlP-dep_Trfase_major; 1.
DR TIGRFAMs; TIGR02006; IscS; 1.
DR PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1.
PE 3: Inferred from homology;
KW Complete proteome; Pyridoxal phosphate; Transferase.
FT CHAIN 1 404 Cysteine desulfurase.
FT /FTId=PRO_1000119634.
FT ACT_SITE 328 328 Cysteine persulfide intermediate (By
FT similarity).
FT MOD_RES 206 206 N6-(pyridoxal phosphate)lysine (By
FT similarity).
SQ SEQUENCE 404 AA; 44578 MW; 88D9E6DDE319319E CRC64;
MTVKTPVYLD YAATTPVDKR VAEKMIPYLT ETFGNPASNS HAFGWTAEEA VEKARADIAA
LINADPKEIV FTSGATESDN LAIKGAANFY KTKGKHLITV KTEHKAVLDT MRELERQGFE
VTYLGVQENG LIDLEELKAA IRDDTILISI MWVNNEIGVV QNIPAIGEIC RERKIAFHVD
AAQACGKVPV DVEAAKIDLL SMSAHKVYGP KGIGALYVRR KPRVRLEAQM HGGGHERGFR
SGTLPTHQIV GMGEAFRIAK EELAQDTAHY LKLRDIFLKG IEGIEEVYIN GDLEHRAPNN
LNVSFNFVEG ESLIMAVKEL AVSSGSACTS ASLEPSYVLR ALGRNDELAH SSLRITFGRM
TTEEEVQFAA ELIKSKIGKL RELSPLWEMF KDGIDLNSIE WAAH
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