ID B4U1G1_STREM Unreviewed; 330 AA.
AC B4U1G1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000256|HAMAP-Rule:MF_00734};
DE EC=4.1.2.40 {ECO:0000256|HAMAP-Rule:MF_00734};
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000256|HAMAP-Rule:MF_00734};
DE AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000256|HAMAP-Rule:MF_00734};
GN Name=lacD {ECO:0000256|HAMAP-Rule:MF_00734,
GN ECO:0000313|EMBL:ACG61828.1};
GN OrderedLocusNames=Sez_0456 {ECO:0000313|EMBL:ACG61828.1};
OS Streptococcus equi subsp. zooepidemicus (strain MGCS10565).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=552526 {ECO:0000313|EMBL:ACG61828.1, ECO:0000313|Proteomes:UP000001873};
RN [1] {ECO:0000313|EMBL:ACG61828.1, ECO:0000313|Proteomes:UP000001873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGCS10565 {ECO:0000313|EMBL:ACG61828.1,
RC ECO:0000313|Proteomes:UP000001873};
RX PubMed=18716664; DOI=10.1371/journal.pone.0003026;
RA Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R.,
RA Musser J.M.;
RT "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain
RT causing epidemic nephritis: new information about an old disease.";
RL PLoS ONE 3:E3026-E3026(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000256|ARBA:ARBA00000567, ECO:0000256|HAMAP-
CC Rule:MF_00734};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005191, ECO:0000256|HAMAP-
CC Rule:MF_00734}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family.
CC {ECO:0000256|ARBA:ARBA00008679, ECO:0000256|HAMAP-Rule:MF_00734}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001129; ACG61828.1; -; Genomic_DNA.
DR RefSeq; WP_012515104.1; NC_011134.1.
DR AlphaFoldDB; B4U1G1; -.
DR KEGG; sez:Sez_0456; -.
DR HOGENOM; CLU_058971_0_1_9; -.
DR UniPathway; UPA00704; UER00716.
DR Proteomes; UP000001873; Chromosome.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR NCBIfam; TIGR01232; lacD; 1.
DR PANTHER; PTHR39340; SULFOFRUCTOSEPHOSPHATE ALDOLASE; 1.
DR PANTHER; PTHR39340:SF1; SULFOFRUCTOSEPHOSPHATE ALDOLASE; 1.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736, ECO:0000256|HAMAP-
KW Rule:MF_00734};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00734}.
SQ SEQUENCE 330 AA; 36842 MW; 3DD5951B2CB43852 CRC64;
MTLTRNKKAY LEKVSRKGII SALAFDQRGA LKRMMAAHQD IEPAPWQIEA LKALVSEELT
PYASSILLDP EYGLPATKVR DERSGLLLAY EQTGYDTTTT SRLPDCLVDW SVKRLKEAGA
DAVKFLLYYD VDGDERINQQ KQAYIERIGS ECQAEEIPFF LELLTYDEAI TDNQSVAFAK
LKAHKVNEAM KVFSAERFGV DVLKVEVPVN MAYVEGFAEG EAVYSKEEAI QAFRDQESAS
HLPYIYLSAG VSASLFQETL VFAAEAGARF NGVLCGRATW SGAVAVYMSE GEEAARQWLR
TEGFQNIDRL NQVLERTASP WTTKLTVDEA
//
