ID B4V8P8_9ACTN Unreviewed; 447 AA.
AC B4V8P8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=FAD-dependent oxidoreductase {ECO:0000313|EMBL:EDX24335.1};
DE SubName: Full=FAD-linked oxidoreductase {ECO:0000313|EMBL:AKL68283.1};
GN ORFNames=M444_25860 {ECO:0000313|EMBL:AKL68283.1}, SSAG_04126
GN {ECO:0000313|EMBL:EDX24335.1};
OS Streptomyces sp. Mg1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=465541 {ECO:0000313|EMBL:EDX24335.1, ECO:0000313|Proteomes:UP000005764};
RN [1] {ECO:0000313|EMBL:EDX24335.1, ECO:0000313|Proteomes:UP000005764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:EDX24335.1,
RC ECO:0000313|Proteomes:UP000005764};
RG The Broad Institute Genome Sequencing Platform;
RA Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA Hepburn T., Sykes S., Mehta T., Alvarado L., Kodira C.D., Straight P.,
RA Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA Lander E., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces sp. Mg1.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKL68283.1, ECO:0000313|Proteomes:UP000035653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL68283.1,
RC ECO:0000313|Proteomes:UP000035653};
RX PubMed=23908282;
RA Hoefler B.C., Konganti K., Straight P.D.;
RT "De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using PacBio
RT Single-Molecule Sequencing.";
RL Genome Announc. 1:e00535-13(2013).
RN [3] {ECO:0000313|EMBL:AKL68283.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mg1 {ECO:0000313|EMBL:AKL68283.1};
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005147}.
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DR EMBL; CP011664; AKL68283.1; -; Genomic_DNA.
DR EMBL; DS570409; EDX24335.1; -; Genomic_DNA.
DR RefSeq; WP_008741358.1; NZ_DS570409.1.
DR AlphaFoldDB; B4V8P8; -.
DR STRING; 465541.M444_25860; -.
DR KEGG; strm:M444_25860; -.
DR PATRIC; fig|465541.12.peg.5461; -.
DR eggNOG; COG0277; Bacteria.
DR HOGENOM; CLU_003896_4_3_11; -.
DR OrthoDB; 9800184at2; -.
DR UniPathway; UPA00132; -.
DR Proteomes; UP000005764; Unassembled WGS sequence.
DR Proteomes; UP000035653; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0003885; F:D-arabinono-1,4-lactone oxidase activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0019853; P:L-ascorbic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2520; -; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR007173; ALO_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR010031; FAD_lactone_oxidase-like.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR006093; Oxy_OxRdtase_FAD_BS.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR NCBIfam; TIGR01679; bact_FAD_ox; 1.
DR PANTHER; PTHR43762; L-GULONOLACTONE OXIDASE; 1.
DR PANTHER; PTHR43762:SF1; L-GULONOLACTONE OXIDASE; 1.
DR Pfam; PF04030; ALO; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR PIRSF; PIRSF000136; LGO_GLO; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
DR PROSITE; PS00862; OX2_COVAL_FAD; 1.
PE 4: Predicted;
KW Ascorbate biosynthesis {ECO:0000256|ARBA:ARBA00022644};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000035653}.
FT DOMAIN 24..197
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 447 AA; 48155 MW; 5304B14D414C45A0 CRC64;
MGTATAGKSG RGTPAAWRNW AGNVTAAPAR VVTPTSVGEL QDVVRRAAED GLRVKAVGTG
HSFTAAAATD GVLVRPQALS GIQAIDREAG TVTVAAGTVL KDLNLALARE GLSLTNMGDI
MDQTVSGATS TGTHGTGRDS ASIAAQIRAL DLVTADGRLL NCSEKGTDEE REVFAAARLG
IGALGIVTAL TFAVEPLFLL TAREEPMAFD RVTAEFDEHV AENEHFEFYW FPHTGNCNTK
RNNRSQGPAA PPGAVSSWVE DELLSNGIFQ AVNSLGRAVP AAIPAIARVA SRALSARTYT
DIPYKVFTSP RRVRFVEMEY ALPRERVVEA LRELKRLVDG SDLRISFPVE VRTAPADDIP
LSTASGRETA YIAVHMYRGT PYQAYFTAAE RIFTAHGGRP HWGKVHTRDA EYLAGAYPRF
GEFTALRDRL DPERLFGNDY LRRVLGA
//
