ID   B4VRB3_9CYAN            Unreviewed;       344 AA.
AC   B4VRB3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:EDX75377.1};
GN   ORFNames=MC7420_1295 {ECO:0000313|EMBL:EDX75377.1};
OS   Coleofasciculus chthonoplastes PCC 7420.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Coleofasciculales;
OC   Coleofasciculaceae; Coleofasciculus.
OX   NCBI_TaxID=118168 {ECO:0000313|EMBL:EDX75377.1, ECO:0000313|Proteomes:UP000003835};
RN   [1] {ECO:0000313|EMBL:EDX75377.1, ECO:0000313|Proteomes:UP000003835}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7420 {ECO:0000313|EMBL:EDX75377.1,
RC   ECO:0000313|Proteomes:UP000003835};
RA   Tandeau de Marsac N., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR   EMBL; DS989849; EDX75377.1; -; Genomic_DNA.
DR   RefSeq; WP_006101088.1; NZ_DS989849.1.
DR   AlphaFoldDB; B4VRB3; -.
DR   STRING; 118168.MC7420_1295; -.
DR   eggNOG; COG0523; Bacteria.
DR   HOGENOM; CLU_017452_1_0_3; -.
DR   OrthoDB; 517607at2; -.
DR   Proteomes; UP000003835; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR012824; CobW.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR02475; CobW; 1.
DR   PANTHER; PTHR13748; COBW-RELATED; 1.
DR   PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003835}.
FT   DOMAIN          5..203
FT                   /note="CobW/HypB/UreG nucleotide-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02492"
FT   DOMAIN          254..342
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07683"
SQ   SEQUENCE   344 AA;  38552 MW;  16C32BA071AA1204 CRC64;
     MHKIPVTVIT GFLGSGKTTL MRHLLQNNQG RKIAVLVNEF GEVGIDGELL RSCQICDEED
     NPNDNIVELT NGCLCCTVQE EFYPTMQQLL QRRDRIDCML IETSGLALPK PLVQAFRWTP
     IRNGATVDGV ITVVDCQALA AGTLVGDINA LEAQRQADPN LDHETPIEEL FEDQLACADL
     VLLTKVDLVD EATLTRIKDW LQDQLPTGVK VIPCDQGQIQ PELLLGFNAA VEDNLDNRPS
     HHDTEDDHDH DDEINSVQFI SDQAFEPKPL IAKLQQLVQQ QEIYRIKGFV SVPNKPMRLV
     LQGVGNRFDS FYDRLWHNGE SRQTRLVLIG RKLDQADIEQ AIGS
//