ID   B4XTZ3_9NOST            Unreviewed;       506 AA.
AC   B4XTZ3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Microcystin synthetase {ECO:0000313|EMBL:ABW96248.1};
DE   Flags: Fragment;
GN   Name=mcyA {ECO:0000313|EMBL:ABW96248.1};
OS   Anabaena sp. 1tu46s11.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=473805 {ECO:0000313|EMBL:ABW96248.1};
RN   [1] {ECO:0000313|EMBL:ABW96248.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1tu46s11 {ECO:0000313|EMBL:ABW96248.1};
RX   PubMed=18375794; DOI=10.1099/mic.0.2007/016097-0;
RA   Fewer D.P., Tooming-Klunderud A., Jokela J., Wahlsten M., Rouhiainen L.,
RA   Kristensen T., Rohrlack T., Jakobsen K.S., Sivonen K.;
RT   "Natural occurrence of microcystin synthetase deletion mutants capable of
RT   producing microcystins in strains of the genus Anabaena (Cyanobacteria).";
RL   Microbiology 154:1007-1014(2008).
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DR   EMBL; EU122311; ABW96248.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4XTZ3; -.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR022583; Microcystin_synth_DUF.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF12593; McyA_C; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          141..241
FT                   /note="Methyltransferase type 12"
FT                   /evidence="ECO:0000259|Pfam:PF08242"
FT   DOMAIN          443..485
FT                   /note="Microcystin synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF12593"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABW96248.1"
FT   NON_TER         506
FT                   /evidence="ECO:0000313|EMBL:ABW96248.1"
SQ   SEQUENCE   506 AA;  57935 MW;  A364645004C31262 CRC64;
     DGNIEFLGRI DHQVKIRGFR IELGEIETVL SHHPAVEQSI VIVHEEETGH KSLIAYIVGN
     SQPSDAVEHN QEVNLFDEQI LQWQMLYNQT YSQANLEPDP MFNIVGWNSS YTGQPIPAVQ
     MRDWLNDKVE TILAQQPNRV LEIGCGTGLI LFQIAPYCRH YWGTDISSRG LDYIQQHLSK
     PESQLHHVNL SQRPADNFEG LEAQGFDTII LNSVVQYFPH IDYLLRVLEG AVNTVAPGGC
     IFLGDVRNLQ LLEAFHTSVE LHKASPDLSV AQWQQQVQRR IAQENELLID PAFFAAIQQR
     FPQITHVQIH LQRGQHHNEL TQFRYNVLLY VGTTVDVPHD IQWLDWQNQK LTLAMVQHLL
     AEAKPEILGI TRLLNPRLIK PLKTLELLKN PHKFQTVSQL RQSIDAISPE AGVELDDLYA
     LAEALSYSLV VSWSDSSVLG YYDVIFVQHQ SQAKVPLRVF TPTNGQAKPL HDWQFYANQP
     LQPRLNRQLI PQLRSYSESR LPEYMM
//