ID B4ZEI9_SCYMA Unreviewed; 232 AA.
AC B4ZEI9;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Nerve growth factor beta polypeptide {ECO:0000313|EMBL:ACF32307.1};
DE Flags: Fragment;
GN Name=NGF {ECO:0000313|EMBL:ACF32307.1};
OS Scytalopus magellanicus (Magellanic tapaculo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Rhinocryptidae; Scytalopus.
OX NCBI_TaxID=9169 {ECO:0000313|EMBL:ACF32307.1};
RN [1] {ECO:0000313|EMBL:ACF32307.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18583609; DOI=10.1126/science.1157704;
RA Hackett S.J., Kimball R.T., Reddy S., Bowie R.C., Braun E.L., Braun M.J.,
RA Chojnowski J.L., Cox W.A., Han K.L., Harshman J., Huddleston C.J.,
RA Marks B.D., Miglia K.J., Moore W.S., Sheldon F.H., Steadman D.W.,
RA Witt C.C., Yuri T.;
RT "A phylogenomic study of birds reveals their evolutionary history.";
RL Science 320:1763-1768(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783}.
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DR EMBL; EU740203; ACF32307.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001789-1}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..232
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012180951"
FT DOMAIN 120..224
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 19..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 128..193
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 171..221
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 181..223
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF32307.1"
SQ SEQUENCE 232 AA; 25603 MW; A9B872E3D57E4343 CRC64;
LYYTLIVAFL IGTQAAPKSE GNAPLEFPAE HSLPNPHRSD RHGVPEAAPQ TPPGHXARRG
ALNVTVDPKI FKKRRFRSPR VLFSTEPPPV AGRAQDLGFL GPAGALNRTA RTKRSTHPVL
HRGEFSVCDS VSMWVGDKTT ATDIKGKEVT VLGEVNINNN VFKQYFFETK CREPKPVSGG
CRGIDAKHWN SYCTTTHTFV KALTMEGKQA AWRFIRIDTA CVCVLSRKAA RP
//
