ID B5A282_9CALI Unreviewed; 437 AA.
AC B5A282;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Polymerase {ECO:0000313|EMBL:ACF34344.1};
DE Flags: Fragment;
OS Norovirus Hu/GII.4/Shenzhen179-06/2006/CHN.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
OX NCBI_TaxID=545143 {ECO:0000313|EMBL:ACF34344.1};
RN [1] {ECO:0000313|EMBL:ACF34344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hu/GII.4/Shenzhen179-06/2006/CHN {ECO:0000313|EMBL:ACF34344.1};
RA He Y.Q., Wu W.L., Cheng J.Q., Yin X.Y., Yang H., Sun H.H., Zhang H.L.,
RA Yao X.J., Chen W.J.;
RT "Epidemiologic and Virologic Investigation of Acute Gastroenteritis in
RT Southern China, 2006.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Viral genome-linked protein is covalently linked to the 5'-
CC end of the positive-strand, negative-strand genomic RNAs and subgenomic
CC RNA. Acts as a genome-linked replication primer. May recruit ribosome
CC to viral RNA thereby promoting viral proteins translation.
CC {ECO:0000256|ARBA:ARBA00025359}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00001491};
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DR EMBL; EU794713; ACF34344.1; -; Genomic_RNA.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23192; Caliciviridae_RdRp; 1.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 6.10.250.3230; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 197..318
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF34344.1"
FT NON_TER 437
FT /evidence="ECO:0000313|EMBL:ACF34344.1"
SQ SEQUENCE 437 AA; 48907 MW; 0D3C167F9076FD8B CRC64;
TYEPAYLGGK DPRVKDGPSL QQVMRDQLKP FTEPRGKPPK PSVLEAAKKT IINVLEQTID
PPEKWSFAQA CASLDKTTSS GHPHHMRKND CWNGESFTGK LADQASKANL MFEEGKNMTP
VYTGALKDEL VKTDKIYGKI KKRLLWGSDL ATMIRCARAF GGLMDELKAH CVTLPIRVGM
NMNEDGPIIF EKHSRYRYHY DADYSRWDST QQRAVLAAAL EIMVKFSSEP HLAQVVAEDL
LSPSVVDVGD FTISINEGLP SGVPCTSQWN SIAHWLLTLC ALSEVTNLSP DIIQANSLFS
FYGDDEIVST DIKLDPEKLT TKLKEYGLKP TRPDKTEGPL VISEDLDGLT FLRRTVTRDP
AGWFGKLEQS SILRQMYWTR GPNHEDPFES MIPHSQRPIQ LMSLLGEAAL HGPTFYSKIS
KLVIAELKEG GMDFYVP
//
