ID B5AFY0_CAPHI Unreviewed; 394 AA.
AC B5AFY0;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=BMP15 {ECO:0000313|EMBL:AFH75124.1};
DE SubName: Full=Bone morphogenetic protein 15 {ECO:0000313|EMBL:ACF24873.1};
DE SubName: Full=Growth differentiation factor 9B {ECO:0000313|EMBL:ADE73871.1};
GN Name=Bmp15 {ECO:0000313|EMBL:ACJ61256.1};
GN Synonyms=BMP15 {ECO:0000313|EMBL:ADE73871.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|EMBL:ACF24873.1};
RN [1] {ECO:0000313|EMBL:ACJ61256.1}
RP NUCLEOTIDE SEQUENCE.
RA Lin J.B., Du Z.Y., Qin C., Wang J.F., Ran X.Q.;
RT "Polymorphism of BMP15 Gene in Guizhou White Goats.";
RL Xu Mu Yu Shou Yi 39:21-24(2007).
RN [2] {ECO:0000313|EMBL:ACJ61256.1}
RP NUCLEOTIDE SEQUENCE.
RA Ran X.Q., Wang J.F., Lin J.B.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ACF24873.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Ovary {ECO:0000313|EMBL:ACF24873.1};
RX PubMed=18987334; DOI=10.1095/biolreprod.108.069021;
RA Cui H.X., Zhao S.M., Cheng M.L., Guo L., Ye R.Q., Liu W.Q., Gao S.Z.;
RT "Cloning and expression levels of genes relating to the ovulation rate of
RT the Yunling black goat.";
RL Biol. Reprod. 80:219-226(2009).
RN [4] {ECO:0000313|EMBL:ADE73871.1}
RP NUCLEOTIDE SEQUENCE.
RA Ghoreishi H., Fathi Yosefabad S., Shayegh J., Barzegari A., Mikaili P.,
RA Maheri-Sis N.;
RT "Polymorphisms in Bone Morphogenetic Protein 15 (BMP15) Gene in Markhoz
RT Goats in Iran.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AFH75124.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23299026; DOI=10.1016/j.gene.2012.12.015;
RA Ahlawat S., Sharma R., Maitra A.;
RT "Screening of indigenous goats for prolificacy associated DNA markers of
RT sheep.";
RL Gene 517:128-131(2013).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; EU847289; ACF24873.1; -; mRNA.
DR EMBL; FJ429281; ACJ61256.1; -; Genomic_DNA.
DR EMBL; GU732196; ADE73871.1; -; Genomic_DNA.
DR EMBL; JQ350891; AFH75124.1; -; Genomic_DNA.
DR EMBL; JQ350892; AFH75125.1; -; Genomic_DNA.
DR AlphaFoldDB; B5AFY0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19402; TGF_beta_GDF9B; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF22; BONE MORPHOGENETIC PROTEIN 15; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..394
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010959534"
FT DOMAIN 266..394
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 394 AA; 45034 MW; F09CE6623856CEF7 CRC64;
MVLLSILRIL LLWGLVLFME HRVQMTQVGQ PSIAHLPEAP TLPLIQELLE EAPGKQQRKP
RVLGHPLRYM LELYQRSADA SGHPRENRTI GATMVRLVRP LASVARPLRG SWHIQTLDFP
LRPNRVAYQL VRATVVYRHQ LHLTHSHLSC HVEPWGQKSP TNHFPSSGRG SPKPSLLPKT
WTEMDIMEHV GQKLWNHKGR RVLRLRFVCQ QPRGSEVLEF WWHGTSSLDT VFLLLYFNDT
QSVQKTKPLP KGLKEFTEKD PSLLLRRARQ AGSIASEVPG PSREHDGPES NQCSLHPFQV
SFQQLGWDHW IIAPHLYTPN YCKGVCPRVL YYGLNSPNHA IIQNLVNELV DQNVPQPSCV
PYKYVPISIL LIEANGSILY KEYEGMIAQS CTCR
//
