ID B5DQ57_DROPS Unreviewed; 130 AA.
AC B5DQ57; A0A6I8V0X8;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Probable insulin-like peptide 3 {ECO:0000313|RefSeq:XP_002135097.1};
GN Name=LOC6900737 {ECO:0000313|RefSeq:XP_002135097.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_002135097.1};
RN [1] {ECO:0000313|RefSeq:XP_002135097.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_002135097.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_002135097.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR RefSeq; XP_002135097.1; XM_002135061.3.
DR AlphaFoldDB; B5DQ57; -.
DR STRING; 46245.B5DQ57; -.
DR EnsemblMetazoa; FBtr0276944; FBpp0275382; FBgn0245261.
DR GeneID; 6900737; -.
DR KEGG; dpo:6900737; -.
DR eggNOG; ENOG502S3FQ; Eukaryota.
DR HOGENOM; CLU_125164_0_1_1; -.
DR InParanoid; B5DQ57; -.
DR OMA; VYGFNAM; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0245261; Expressed in insect adult head.
DR ExpressionAtlas; B5DQ57; baseline.
DR GO; GO:0005615; C:extracellular space; IEA:EnsemblMetazoa.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0060180; P:female mating behavior; IEA:EnsemblMetazoa.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0045475; P:locomotor rhythm; IEA:EnsemblMetazoa.
DR GO; GO:0061964; P:negative regulation of entry into reproductive diapause; IEA:EnsemblMetazoa.
DR GO; GO:0009743; P:response to carbohydrate; IEA:EnsemblMetazoa.
DR GO; GO:0030431; P:sleep; IEA:EnsemblMetazoa.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR040228; Insulin-relat-peptide_inver.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR13647; INSULIN-LIKE PEPTIDE 2-RELATED; 1.
DR PANTHER; PTHR13647:SF6; INSULIN-LIKE PEPTIDE 2-RELATED; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Secreted {ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 29..121
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 130 AA; 14536 MW; 73B2262708E99431 CRC64;
MQQTKSKSLY LVLILVGLVV MGQQTAADMY LCGTELNDAL STMCGRHGYN RMLKRSFDPT
DYNDIEGGFG LARMEFDDRS LLHRMLGESA AQLMKTRRRR VGVSDECCLK PCSLGELLNY
CAKPPGQYGN
//
