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Database: UniProt
Entry: B5EZK3
LinkDB: B5EZK3
Original site: B5EZK3 
ID   NUOH_SALA4              Reviewed;         325 AA.
AC   B5EZK3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   09-JUL-2014, entry version 38.
DE   RecName: Full=NADH-quinone oxidoreductase subunit H;
DE            EC=1.6.99.5;
DE   AltName: Full=NADH dehydrogenase I subunit H;
DE   AltName: Full=NDH-1 subunit H;
GN   Name=nuoH; OrderedLocusNames=SeAg_B2461;
OS   Salmonella agona (strain SL483).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=454166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL483;
RX   PubMed=21602358; DOI=10.1128/JB.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be ubiquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient. This subunit may
CC       bind ubiquinone (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC   -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits
CC       NuoA, H, J, K, L, M, N constitute the membrane sector of the
CC       complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (Potential).
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family.
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DR   EMBL; CP001138; ACH52925.1; -; Genomic_DNA.
DR   RefSeq; YP_002147280.1; NC_011149.1.
DR   STRING; 454166.SeAg_B2461; -.
DR   PRIDE; B5EZK3; -.
DR   EnsemblBacteria; ACH52925; ACH52925; SeAg_B2461.
DR   PATRIC; 18483206; VBISalEnt65316_2409.
DR   eggNOG; COG1005; -.
DR   HOGENOM; HOG000228276; -.
DR   OMA; GAFRNFA; -.
DR   OrthoDB; EOG6B62B4; -.
DR   BioCyc; SENT454166:GHBA-2439-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD;
KW   Oxidoreductase; Quinone; Transmembrane; Transmembrane helix;
KW   Ubiquinone.
FT   CHAIN         1    325       NADH-quinone oxidoreductase subunit H.
FT                                /FTId=PRO_1000143617.
FT   TRANSMEM     11     31       Helical; (Potential).
FT   TRANSMEM     50     69       Helical; (Potential).
FT   TRANSMEM     81    101       Helical; (Potential).
FT   TRANSMEM    114    134       Helical; (Potential).
FT   TRANSMEM    154    174       Helical; (Potential).
FT   TRANSMEM    186    206       Helical; (Potential).
FT   TRANSMEM    237    257       Helical; (Potential).
FT   TRANSMEM    265    285       Helical; (Potential).
FT   TRANSMEM    304    324       Helical; (Potential).
SQ   SEQUENCE   325 AA;  36292 MW;  85A7F3A941EA873D CRC64;
     MSWITPDLIE ILLSILKAVV ILLVVVTCGA FMSFGERRLL GLFQNRYGPN RVGWGGSLQL
     VADMIKMFFK EDWIPKFSDR VIFTLAPMIA FTSLLLSFAI VPVSPNWVVA DLNIGILFFL
     MMAGLAVYAV LFAGWSSNNK YSLLGAMRAS AQTVSYEVFL GLSLMGVVAQ AGSFNMTDIV
     NNQAHLWNVI PQFFGFVTFA IAGVAVCHRH PFDQPEAEQE LADGYHIEYS GMKFGLFFVG
     EYIGIVTVSA LMVTLFFGGW HGPFLPPFVW FALKTAFFMM MFILIRASLP RPRYDQVMSF
     GWKVCLPLTL INLLVTAAVI LWQAQ
//
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