ID B5G124_TAEGU Unreviewed; 214 AA.
AC B5G124;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Methyltransferase-like protein 5 {ECO:0000256|ARBA:ARBA00041374};
GN Name=METTL5 {ECO:0000313|Ensembl:ENSTGUP00000008246.1};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|EMBL:ACH44985.1};
RN [1] {ECO:0000313|EMBL:ACH44985.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole brain {ECO:0000313|EMBL:ACH44985.1};
RX PubMed=17018643; DOI=10.1073/pnas.0607098103;
RA Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V.,
RA Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S.,
RA Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P.,
RA Hayashizaki Y., Carninci P., Jarvis E.D.;
RT "A molecular neuroethological approach for identifying and characterizing a
RT cascade of behaviorally regulated genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008246.1, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [3] {ECO:0000313|Ensembl:ENSTGUP00000008246.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. PrmA family.
CC {ECO:0000256|ARBA:ARBA00009741}.
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DR EMBL; DQ215336; ACH44985.1; -; mRNA.
DR EMBL; DQ215337; ACH44986.1; -; mRNA.
DR EMBL; DQ215338; ACH44987.1; -; mRNA.
DR EMBL; DQ215339; ACH44988.1; -; mRNA.
DR RefSeq; NP_001232502.1; NM_001245573.1.
DR RefSeq; XP_002198453.1; XM_002198417.3.
DR STRING; 59729.ENSTGUP00000008246; -.
DR Ensembl; ENSTGUT00000008333.2; ENSTGUP00000008246.1; ENSTGUG00000007994.2.
DR GeneID; 100190368; -.
DR KEGG; tgu:100190368; -.
DR CTD; 29081; -.
DR GeneTree; ENSGT00390000000227; -.
DR HOGENOM; CLU_074702_1_1_1; -.
DR OMA; DVVYSIH; -.
DR OrthoDB; 178393at2759; -.
DR TreeFam; TF314953; -.
DR Proteomes; UP000007754; Chromosome 7.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008988; F:rRNA (adenine-N6-)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:1904047; F:S-adenosyl-L-methionine binding; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR PANTHER; PTHR23290:SF0; RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5; 1.
DR PANTHER; PTHR23290; UNCHARACTERIZED; 1.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 46..146
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 214 AA; 24098 MW; FA5B948E381E392F CRC64;
MKKLKLKELE SCLQQVDTFE NPKLLLEQYP TRPHIAACML YTIHNTFDDI ENKTIADLGC
GCGMLSIGSA MLGAGFCVGL DIDADALEIF NSNIEDFDLT NVNMVQCDIC SLSDSMSDTF
DTVIMNPPFG TKHNKGIDMI FLKTALQMAK TAVYSLHKTS TRQHIQKKAA EWEVKMEVLA
ELRFDLPASY KFHKKKSVDI EVDFIRFSAK KVLN
//
