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Database: UniProt
Entry: B5GTV2_STRC2
LinkDB: B5GTV2_STRC2
Original site: B5GTV2_STRC2 
ID   B5GTV2_STRC2            Unreviewed;       402 AA.
AC   B5GTV2;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   25-OCT-2017, entry version 65.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=exL {ECO:0000313|EMBL:EFG09029.1};
GN   Synonyms=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=SCLAV_3955 {ECO:0000313|EMBL:EFG09029.1}, SSCG_02696
GN   {ECO:0000313|EMBL:EDY49748.1};
OS   Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 /
OS   NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=443255 {ECO:0000313|EMBL:EDY49748.1, ECO:0000313|Proteomes:UP000006569};
RN   [1] {ECO:0000313|EMBL:EDY49748.1, ECO:0000313|Proteomes:UP000006569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27064 {ECO:0000313|EMBL:EDY49748.1}, and ATCC 27064 / DSM
RC   738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602
RC   {ECO:0000313|Proteomes:UP000006569};
RG   The Broad Institute Genome Sequencing Platform;
RA   Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A.,
RA   Heiman D., Hepburn T., Sykes S., Godfrey P., Alvarado L., Kodira C.D.,
RA   Straight P., Clardy J., Hung D., Kolter R., Mekalanos J., Walker S.,
RA   Walsh C.T., Lander E., Galagan J., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces clavuligerus ATCC 27064.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EFG09029.1, ECO:0000313|Proteomes:UP000002357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27064 {ECO:0000313|EMBL:EFG09029.1}, and ATCC 27064 / DSM
RC   738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602
RC   {ECO:0000313|Proteomes:UP000002357};
RX   PubMed=20624727; DOI=10.1093/gbe/evq013;
RA   Medema M.H., Trefzer A., Kovalchuk A., van den Berg M., Mueller U.,
RA   Heijne W., Wu L., Alam M.T., Ronning C.M., Nierman W.C.,
RA   Bovenberg R.A.L., Breitling R., Takano E.;
RT   "The sequence of a 1.8-mb bacterial linear plasmid reveals a rich
RT   evolutionary reservoir of secondary metabolic pathways.";
RL   Genome Biol. Evol. 2:212-224(2010).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; DS570644; EDY49748.1; -; Genomic_DNA.
DR   EMBL; CM000913; EFG09029.1; -; Genomic_DNA.
DR   RefSeq; WP_003955254.1; NZ_DS570644.1.
DR   STRING; 443255.SclaA2_010100018973; -.
DR   EnsemblBacteria; EDY49748; EDY49748; SSCG_02696.
DR   EnsemblBacteria; EFG09029; EFG09029; SCLAV_3955.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000002357; Chromosome.
DR   Proteomes; UP000006569; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 2.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002357,
KW   ECO:0000313|Proteomes:UP000006569};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:EFG09029.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002357}.
FT   DOMAIN       12    105       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      129    349       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   DOMAIN      336    396       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   402 AA;  43823 MW;  7588A23E44620D03 CRC64;
     MALHTSPDAP LPVGEVSRLI GGWIDRLGAI WVEGQITQLS RRPGQGVVFL TLRDPSHDIS
     VSVTCYRQVF DAVADVVSEG ARVVVHAKPE WYAPRGQLSL RAAELRPVGV GELLARLEQL
     KRSLAAEGLF GPERKKRLPF LPHRVGLVCG RASAAERDVL ENARRRWPAV RFEVRNVAVQ
     GVHAVPQVVG AVQELDALPE VDVIIVARGG GSVEDLLPFS DEQLVRAVAG CRTPVVSAIG
     HEPDSPLLDL VADLRASTPT DAAKKVVPDV GEELERVRQL RGRALRTVRS LLDREERGLA
     HALARPVLER PHRMVEEREA EVEALAARGR RVLGHLLDRA ESELAHTRAR VVALSPAATL
     ERGYAVLQRP DGAVVRDPDE VAAGEELRAR VARGTFPVRV AE
//
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