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Database: UniProt
Entry: B5I768_9ACTN
LinkDB: B5I768_9ACTN
Original site: B5I768_9ACTN 
ID   B5I768_9ACTN            Unreviewed;       505 AA.
AC   B5I768;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 2.
DT   25-OCT-2017, entry version 47.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=SSEG_07503 {ECO:0000313|EMBL:EDY60923.2};
OS   Streptomyces sviceus ATCC 29083.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=463191 {ECO:0000313|EMBL:EDY60923.2, ECO:0000313|Proteomes:UP000002785};
RN   [1] {ECO:0000313|Proteomes:UP000002785}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29083 {ECO:0000313|Proteomes:UP000002785};
RG   The Broad Institute Genome Sequencing Platform;
RA   Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A.,
RA   Heiman D., Hepburn T., Sykes S., Alvarado L., Kodira C.D.,
RA   Straight P., Clardy J., Hung D., Kolter R., Mekalanos J., Walker S.,
RA   Walsh C.T., Lander E., Galagan J., Nusbaum C., Birren B.;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDY60923.2, ECO:0000313|Proteomes:UP000002785}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29083 {ECO:0000313|EMBL:EDY60923.2,
RC   ECO:0000313|Proteomes:UP000002785};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S.N., Thomson T., Walk T., White J., Yandava C., Straight P.,
RA   Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA   Wieland-Brown L.C., Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces sviceus strain ATCC 29083.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CM000951; EDY60923.2; -; Genomic_DNA.
DR   STRING; 463191.SSEG_07503; -.
DR   EnsemblBacteria; EDY60923; EDY60923; SSEG_07503.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; SSVI463191:G12KZ-4219-MONOMER; -.
DR   Proteomes; UP000002785; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002785};
KW   DNA replication {ECO:0000256|RuleBase:RU004227};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002785}.
FT   DOMAIN      380    503       AAA. {ECO:0000259|SMART:SM00382}.
SQ   SEQUENCE   505 AA;  56701 MW;  0D88B3E268C51F30 CRC64;
     MSFGSTPFES RLVPQPHVRG TRERACPVAD VPADLAAVWP RVLEQLLGEG RVQGVEAKDE
     HWIRRCQPLA LVADTALLAV PNEFAKGVLE GRLAPAVSET LSRECGRPIR IAITVDDSAG
     EPSPPPSPPA PRPQSRYEEP ELPSGQYDNQ YEGYGRHRAD DSHQSRGEQR PAHQGDRAPR
     PDQLPTARPA YPSEYQRPEP GAWPRPAQDE YSWQQQRLGF PERDPYASPS QEPYPQEPYQ
     QEPYTQESYG PSSQDYRPQS MERPSYDGPR SDYNQRPDYD KPRPDYDQPR SDYDQRDSRR
     DLPDPPSGSG RVHRGGPVGS NLPTTGAPGP LAAQPAPATG PGEPTARLNP KYLFDTFVIG
     ASNRFAHAAA VAVAEAPAKA YNPLFIYGES GLGKTHLLHA IGHYARSLYP GTRVRYVSSE
     EFTNEFINSI RDGKGDSFRK RYREMDILLV DDIQFLADKE STQEEFFHTF NTLHNANKQI
     VLSSDRPPKQ LVTLEDRLRN RFEWV
//
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