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Database: UniProt
Entry: B5JT30_9GAMM
LinkDB: B5JT30_9GAMM
Original site: B5JT30_9GAMM 
ID   B5JT30_9GAMM            Unreviewed;       458 AA.
AC   B5JT30;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   05-JUL-2017, entry version 58.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EDY87004.1};
GN   ORFNames=GP5015_2180 {ECO:0000313|EMBL:EDY87004.1};
OS   gamma proteobacterium HTCC5015.
OC   Bacteria; Proteobacteria; Gammaproteobacteria.
OX   NCBI_TaxID=391615 {ECO:0000313|EMBL:EDY87004.1, ECO:0000313|Proteomes:UP000004692};
RN   [1] {ECO:0000313|Proteomes:UP000004692}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC5015 {ECO:0000313|Proteomes:UP000004692};
RX   PubMed=20472792; DOI=10.1128/JB.00510-10;
RA   Thrash J.C., Stingl U., Cho J.C., Ferriera S., Johnson J.,
RA   Vergin K.L., Giovannoni S.J.;
RT   "Genome sequence of the novel marine member of the Gammaproteobacteria
RT   strain HTCC5015.";
RL   J. Bacteriol. 192:3838-3839(2010).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; DS990599; EDY87004.1; -; Genomic_DNA.
DR   RefSeq; WP_008283708.1; NZ_DS990599.1.
DR   STRING; 391615.GP5015_2180; -.
DR   EnsemblBacteria; EDY87004; EDY87004; GP5015_2180.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004692; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004692};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004692}.
FT   DOMAIN      155    360       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      366    435       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     163    170       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   458 AA;  51700 MW;  7984B3341E7D6E1C CRC64;
     MTQAVWQSCL SQLENELTDH DMNVWIRPLH AEVVNQTLNL MAPNPFVRDW VQEKYQTRIQ
     EILNSLQTEI TQLRISIGSF SAKPAPARDP VVTTTSQSSQ SSAAPAPKPA EPPSQPPVNH
     NLEAGHTFDS FVEGKSNQMA KAAAQHVAQA PGDGYYNPLF LYGGVGLGKT HLMHAVGHAI
     LERNPKARVV YLHSERFVGD MVKALQHNAI DEFKRLYRSV DALLIDDIQF FAGKERSQEE
     FFHTFNALLE RKQQMILTCD RYPKEVNGLE ERLKSRFGWG LTVAIEPPEL EERVAILKSK
     AEIANVDMKD DVAFFIAQKV RSNVRELEGA MKRVIVNSQF TGREITVDFA REQLRDQIAS
     QDRLVTLENI QRTVADYYNI RVADLLSKSR SRSITRPRQI AMALAAELTN HSLPEIGNAF
     GGRDHTTVLH ARRKIQALRA EDGRMNEDCQ NLLRILSS
//
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