ID B5L3Q5_SHIDY Unreviewed; 468 AA.
AC B5L3Q5;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN Name=manC {ECO:0000313|EMBL:ACD36989.1};
OS Shigella dysenteriae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=622 {ECO:0000313|EMBL:ACD36989.1};
RN [1] {ECO:0000313|EMBL:ACD36989.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18422615; DOI=10.1111/j.1574-6976.2008.00114.x;
RA Liu B., Knirel Y.A., Feng L., Perepelov A.V., Senchenkova S.N., Wang Q.,
RA Reeves P.R., Wang L.;
RT "Structure and genetics of Shigella O antigens.";
RL FEMS Microbiol. Rev. 32:627-653(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; EU296402; ACD36989.1; -; Genomic_DNA.
DR AlphaFoldDB; B5L3Q5; -.
DR UniPathway; UPA00126; UER00930.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..284
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 313..461
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 468 AA; 52085 MW; D62082DE702C456B CRC64;
MLLPVVMAGG SGTRLWPLSR TLYPKQFLSL NSRLTMLQET LRRLDKVEHK PALVICNESH
RFIVAEQLRK EGLKHSGILL EPVGRNTVPA VALAALQAMV TGDDPILLVL AADHEIQNED
NFIDAVLAAK NFAEQGKLVT FGIVPTSPET GYGYIKSGEY LDGKGYKVAA FVEKPELHVA
QQYISDGGYL WNSGMFMFRA SVFIDELKKF RPDILASCQR SLSSSIQDLD FIRLDNASFS
CCPEESIDYA VMEKTAEAVV VPLNAQWSDV GSWSALWEIS SKDQSGNAIR GDVLVEDATD
SYLYSQHRLI GAVGIKDLVV VETKDAVLVA HKDKVQQVKN IVAQLKKNNR TEYLQHREIF
RPWGSHDTIA EGPRFQVKHV IVLPGHITAK QIHYHRTEHW IVVSGTAKVH LEDKTYLVSE
NESTYIPVGV PHAIENPGKI PLEIIEVRSG VYLEEDDVIR VSSSGVGY
//
