ID B5LAW4_CAPAN Unreviewed; 471 AA.
AC B5LAW4;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 22-FEB-2023, entry version 50.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:ACF17671.1};
RN [1] {ECO:0000313|EMBL:ACF17671.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19553373; DOI=10.1104/pp.109.136549;
RA Mazourek M., Pujar A., Borovsky Y., Paran I., Mueller L., Jahn M.M.;
RT "A dynamic interface for capsaicinoid systems biology.";
RL Plant Physiol. 150:1806-1821(2009).
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; EU616579; ACF17671.1; -; mRNA.
DR RefSeq; NP_001311888.1; NM_001324959.1.
DR AlphaFoldDB; B5LAW4; -.
DR EnsemblPlants; PHT83858; PHT83858; T459_12301.
DR GeneID; 107867814; -.
DR Gramene; PHT83858; PHT83858; T459_12301.
DR KEGG; cann:107867814; -.
DR OrthoDB; 1399at2759; -.
DR GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR045257; E2/Pdx1.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR23151:SF75; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT 5 OF PYRUVATE DEHYDROGENASE COMPLEX, CHLOROPLASTIC; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Pyruvate {ECO:0000313|EMBL:ACF17671.1};
KW Transferase {ECO:0000256|RuleBase:RU003423};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 38..113
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 181..218
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 471 AA; 49138 MW; 517F505907BEA924 CRC64;
MSHLLQSTFI PTTPTTLRRC SVFPTTHLRK THVVESKIRE IFMPALSSTM TEGKIVSWVK
SEGDKLAKGE SVVVVESDKA DMDVESFYDG YLANIIVPEG SSASVGSTIA LLAESEDEIS
LAKSKTLTTV SSSSQETPPA TVTEEVSPVV SPVAAAVSLS SDAVKIASAI HPASEGGKRV
VASPYAKKLA KELGLDLRGV VGSGPNGRIV AKDVEAAAAA ASDGAAPIGV AAAALKPSGS
APAAPVVDLG TTVPFTTMQN AVSRNMVESL AVPTFRVGYT ITTNALDSLY KKIKSKGVTM
TALLAKATAL ALAKHPVVNS SCRGGKSFTY NSSINIAVAV AIDGGLITPV LQDADKVDLY
SLSRKWKELV DKARAKQLQP HEYTTGTFTL SNLGMFGVDR FDAILPPGTG AIMAVGASLP
TLVGSKDGRI GVKNQMQVNV TADHRVIYGA DLASFLQTLA QIIEDPKDLT L
//