ID B5LZ65_VITVI Unreviewed; 680 AA.
AC B5LZ65;
DT 14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Two pore channel 1 {ECO:0000313|EMBL:ACH53197.1};
GN Name=TPC1 {ECO:0000313|EMBL:ACH53197.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:ACH53197.1};
RN [1] {ECO:0000313|EMBL:ACH53197.1}
RP NUCLEOTIDE SEQUENCE.
RA Paldi T., Damari I., Keren-Keiserman A., Or E., Gurevitz M.;
RT "Molecular cloning of a two pore channel from Vitis vinifera (VvTPC1).";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. Two pore calcium channel subfamily.
CC {ECO:0000256|ARBA:ARBA00009286}.
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DR EMBL; EU925561; ACH53197.1; -; mRNA.
DR RefSeq; NP_001268025.1; NM_001281096.1.
DR AlphaFoldDB; B5LZ65; -.
DR GeneID; 100233073; -.
DR KEGG; vvi:100233073; -.
DR OrthoDB; 5403296at2759; -.
DR ExpressionAtlas; B5LZ65; baseline and differential.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR044581; TPC1_plant.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46988; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46988:SF2; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00022882};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 67..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 367..402
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 680 AA; 79302 MW; F8E07A2F86126FDF CRC64;
MDKPLLDGES SGGRRRGQTP VFHRRSDAIA YGSPYQKAAA LVDLAEDGIG LPEQMLDQES
FESAAKFYFI FIRFNFLWSL NLFALIVLNF LEKPLWCAKQ TTYSCNDREY YFLGQLPYLT
SVESLIYEGI TLVIILSHTF FPISYEGSQI YWKNPLNRLK VILLSILVAD LLVYVLYLSP
LPFYYLPFRL APYIRVILCI LNIREVRATM VILAGMLGTY LNIMALGLLF LLFASWVAYV
MFEDTQQGKT VFTSYLTTLY QMFILFTTSN NPDVWIPAYK VSRWYCLFFV LYMLLGVYFM
TNLILAVIYD SFKNQLAKQV AEMDRMRRRI LEKAFNLIDK SNLGFLKKEQ CIHLFEELNK
YRSLPKISRE DFELIFDELD DSNDFKINLD EFFDLCNAIT LSFQKEDSQS WFERYPSFYH
SPACEKLKAF VRSSIFGNMI AVILVLNLVA VIIETTLDIE NNSAQKVWQK VEFVLGWIYV
LEMALKVFAF GFKNYWRDDS NRFDFFITWI IVIGETATFV APSSLSFLSN GEWIRYLLLA
RMLRLIRLLM RVKQYRAFIA TFLNLIPSLM PYLGTIFCVL CIYCSLGVQS YKDLTGTSWT
LVYFISYYLL TVLLLLNLVV AFVLEAFFAE MDLEKSENCG EDGKEVGEKQ RRYTRSRIRS
QRVDILLHHM LSAELNQTES
//
