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Database: UniProt
Entry: B5R8Z9
LinkDB: B5R8Z9
Original site: B5R8Z9 
ID   NHAP2_SALG2             Reviewed;         577 AA.
AC   B5R8Z9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   09-JUL-2014, entry version 49.
DE   RecName: Full=K(+)/H(+) antiporter NhaP2;
DE   AltName: Full=Potassium/proton antiporter NhaP2;
GN   Name=nhaP2; Synonyms=cvrA; OrderedLocusNames=SG1315;
OS   Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550538;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=287/91 / NCTC 13346;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K.,
RA   Moule S., Mungall K., Saunders M., Whitehead S., Chabalgoity J.A.,
RA   Maskell D., Humphreys T., Roberts M., Barrow P.A., Dougan G.,
RA   Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and
RT   Salmonella gallinarum 287/91 provides insights into evolutionary and
RT   host adaptation pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- FUNCTION: K(+)/H(+) antiporter that extrudes potassium in exchange
CC       for external protons and maintains the internal concentration of
CC       potassium under toxic levels (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
CC       (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
CC   -!- SIMILARITY: Contains 1 RCK C-terminal domain.
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DR   EMBL; AM933173; CAR37192.1; -; Genomic_DNA.
DR   RefSeq; YP_002226333.1; NC_011274.1.
DR   STRING; 550538.SG1315; -.
DR   EnsemblBacteria; CAR37192; CAR37192; EBG00000232807.
DR   PATRIC; 18500943; VBISalEnt1629_1405.
DR   eggNOG; NOG255719; -.
DR   HOGENOM; HOG000019567; -.
DR   OMA; TFDGMAW; -.
DR   OrthoDB; EOG6RZB2N; -.
DR   BioCyc; SENT550538:GJ93-1305-MONOMER; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-HAMAP.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015386; F:potassium:proton antiporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006884; P:cell volume homeostasis; IEA:InterPro.
DR   GO; GO:0043266; P:regulation of potassium ion transport; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.30.70.1450; -; 1.
DR   HAMAP; MF_01075; NhaP2; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR016169; CO_DH_flavot_FAD-bd_sub2.
DR   InterPro; IPR016166; FAD-bd_2.
DR   InterPro; IPR023729; NhaP2.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF116726; SSF116726; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51202; RCK_C; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Complete proteome;
KW   Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    577       K(+)/H(+) antiporter NhaP2.
FT                                /FTId=PRO_1000136712.
FT   TRANSMEM      3     23       Helical; (Potential).
FT   TRANSMEM     30     50       Helical; (Potential).
FT   TRANSMEM     58     78       Helical; (Potential).
FT   TRANSMEM     87    107       Helical; (Potential).
FT   TRANSMEM    119    141       Helical; (Potential).
FT   TRANSMEM    185    205       Helical; (Potential).
FT   TRANSMEM    221    241       Helical; (Potential).
FT   TRANSMEM    271    291       Helical; (Potential).
FT   TRANSMEM    293    313       Helical; (Potential).
FT   TRANSMEM    334    354       Helical; (Potential).
FT   TRANSMEM    363    383       Helical; (Potential).
FT   DOMAIN      403    485       RCK C-terminal.
SQ   SEQUENCE   577 AA;  62451 MW;  5E6AECDFBD7EEC1A CRC64;
     MDAATIISLF ILGSILVTSS ILLSSFSSRL GIPILVIFLA IGMLAGVDGI GGIPFDNYPF
     AYIVSNLALA IILLDGGMRT QASSFRVALG PALSLATLGV LITSGLTGMM AAWLFHLDLI
     EGLLIGAIVG STDAAAVFSL LGGKGLNERV GSTLEIESGS NDPMAVFLTI TLIEMIQKHE
     TGLDWMFAVH IIQQFGLGIV FGLGGGYLLQ QMINRISLPS GLYPMLALSG GILIFALTTA
     LEGSGILAVY LCGFLLGNRP IRNRYGILQN FDGLAWLAQI AMFLVLGLLV TPSDLWPIAV
     PALILSIWMI FFARPLSVFT GLLPFRGFNL RERIFISWVG LRGAVPIILA VFPMMAGLEN
     ARLFFNVAFF VVLVSLLLQG TSLSWAAKRA KVVVPPVGWP VSRVGLDIHP DNPWEQFIYQ
     LSADKWCVGA ALRDLHMPNE TRIAALFRNN ELFHPTGSTR LQEGDVLCVI GRERDLPALG
     KLFSQSPPVS LDQRFFGDFI LEANAKFADV ALIYGLEEGT EYRDKQQTLG EIIQQLLGAA
     PVVGDQVEFG GMIWTVAEKE DNVVRKIGVR VAEDEAE
//
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