ID CVRA_SALG2 Reviewed; 577 AA.
AC B5R8Z9;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 1.
DT 01-MAY-2013, entry version 39.
DE RecName: Full=Cell volume regulation protein A;
GN Name=cvrA; OrderedLocusNames=SG1315;
OS Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=550538;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=287/91 / NCTC 13346;
RX PubMed=18583645; DOI=10.1101/gr.077404.108;
RA Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K.,
RA Moule S., Mungall K., Saunders M., Whitehead S., Chabalgoity J.A.,
RA Maskell D., Humphreys T., Roberts M., Barrow P.A., Dougan G.,
RA Parkhill J.;
RT "Comparative genome analysis of Salmonella enteritidis PT4 and
RT Salmonella gallinarum 287/91 provides insights into evolutionary and
RT host adaptation pathways.";
RL Genome Res. 18:1624-1637(2008).
CC -!- FUNCTION: Participates in control of cell volume in low-osmolarity
CC conditions (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein (Potential).
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
CC (CPA1) transporter (TC 2.A.36) family. CvrA subfamily.
CC -!- SIMILARITY: Contains 1 RCK C-terminal domain.
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DR EMBL; AM933173; CAR37192.1; -; Genomic_DNA.
DR RefSeq; YP_002226333.1; NC_011274.1.
DR STRING; 550538.SG1315; -.
DR EnsemblBacteria; CAR37192; CAR37192; SG1315.
DR GeneID; 6923378; -.
DR KEGG; seg:SG1315; -.
DR PATRIC; 18500943; VBISalEnt1629_1405.
DR eggNOG; NOG255719; -.
DR HOGENOM; HOG000019567; -.
DR KO; K11105; -.
DR OMA; SEWELFV; -.
DR ProtClustDB; PRK05326; -.
DR BioCyc; SENT550538:GJ93-1305-MONOMER; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:HAMAP.
DR GO; GO:0015299; F:solute:hydrogen antiporter activity; IEA:InterPro.
DR GO; GO:0006884; P:cell volume homeostasis; IEA:HAMAP.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:0043266; P:regulation of potassium ion transport; IEA:HAMAP.
DR Gene3D; 3.30.465.10; -; 1.
DR HAMAP; MF_01075; CvrA; 1; -.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR016169; CO_DH_flavot_FAD-bd_sub2.
DR InterPro; IPR023729; CvrA.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR Pfam; PF03471; CorC_HlyC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 577 Cell volume regulation protein A.
FT /FTId=PRO_1000136712.
FT TRANSMEM 3 23 Helical; (Potential).
FT TRANSMEM 30 50 Helical; (Potential).
FT TRANSMEM 58 78 Helical; (Potential).
FT TRANSMEM 87 107 Helical; (Potential).
FT TRANSMEM 119 141 Helical; (Potential).
FT TRANSMEM 185 205 Helical; (Potential).
FT TRANSMEM 221 241 Helical; (Potential).
FT TRANSMEM 271 291 Helical; (Potential).
FT TRANSMEM 293 313 Helical; (Potential).
FT TRANSMEM 334 354 Helical; (Potential).
FT TRANSMEM 363 383 Helical; (Potential).
FT DOMAIN 403 485 RCK C-terminal.
SQ SEQUENCE 577 AA; 62451 MW; 5E6AECDFBD7EEC1A CRC64;
MDAATIISLF ILGSILVTSS ILLSSFSSRL GIPILVIFLA IGMLAGVDGI GGIPFDNYPF
AYIVSNLALA IILLDGGMRT QASSFRVALG PALSLATLGV LITSGLTGMM AAWLFHLDLI
EGLLIGAIVG STDAAAVFSL LGGKGLNERV GSTLEIESGS NDPMAVFLTI TLIEMIQKHE
TGLDWMFAVH IIQQFGLGIV FGLGGGYLLQ QMINRISLPS GLYPMLALSG GILIFALTTA
LEGSGILAVY LCGFLLGNRP IRNRYGILQN FDGLAWLAQI AMFLVLGLLV TPSDLWPIAV
PALILSIWMI FFARPLSVFT GLLPFRGFNL RERIFISWVG LRGAVPIILA VFPMMAGLEN
ARLFFNVAFF VVLVSLLLQG TSLSWAAKRA KVVVPPVGWP VSRVGLDIHP DNPWEQFIYQ
LSADKWCVGA ALRDLHMPNE TRIAALFRNN ELFHPTGSTR LQEGDVLCVI GRERDLPALG
KLFSQSPPVS LDQRFFGDFI LEANAKFADV ALIYGLEEGT EYRDKQQTLG EIIQQLLGAA
PVVGDQVEFG GMIWTVAEKE DNVVRKIGVR VAEDEAE
//
