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Database: UniProt
Entry: B5REZ9
LinkDB: B5REZ9
Original site: B5REZ9 
ID   KHSE_SALG2              Reviewed;         309 AA.
AC   B5REZ9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   11-JUN-2014, entry version 48.
DE   RecName: Full=Homoserine kinase;
DE            Short=HK;
DE            Short=HSK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=SG0003;
OS   Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550538;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=287/91 / NCTC 13346;
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K.,
RA   Moule S., Mungall K., Saunders M., Whitehead S., Chabalgoity J.A.,
RA   Maskell D., Humphreys T., Roberts M., Barrow P.A., Dougan G.,
RA   Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and
RT   Salmonella gallinarum 287/91 provides insights into evolutionary and
RT   host adaptation pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of L-
CC       homoserine to L-homoserine phosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily.
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DR   EMBL; AM933173; CAR35913.1; -; Genomic_DNA.
DR   RefSeq; YP_002225150.1; NC_011274.1.
DR   ProteinModelPortal; B5REZ9; -.
DR   STRING; 550538.SG0003; -.
DR   PRIDE; B5REZ9; -.
DR   EnsemblBacteria; CAR35913; CAR35913; EBG00000232283.
DR   PATRIC; 18498077; VBISalEnt1629_0002.
DR   eggNOG; COG0083; -.
DR   HOGENOM; HOG000269560; -.
DR   OMA; KENIVYQ; -.
DR   OrthoDB; EOG6DG2WK; -.
DR   BioCyc; SENT550538:GJ93-3-MONOMER; -.
DR   UniPathway; UPA00050; UER00064.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; -; 1.
DR   HAMAP; MF_00384; Homoser_kinase; 1.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR   InterPro; IPR000870; Homoserine_kinase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000676; Homoser_kin; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR00191; thrB; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    309       Homoserine kinase.
FT                                /FTId=PRO_1000122439.
FT   NP_BIND      91    101       ATP (Potential).
SQ   SEQUENCE   309 AA;  33286 MW;  2B5D570CB35F8911 CRC64;
     MVKVYAPASS ANMSVGFDVL GAAVTPVDGT LLGDVVSVEA ADHFRLHNLG RFADKLPPEP
     RENIVYQCWE RFCQALGKTI PVAMTLEKNM PIGSGLGSSA CSVVAALVAM NEHCGKPLND
     TRLLALMGEL EGRISGSIHY DNVAPCFLGG MQLMIEENGI ISQQVPGFDE WLWVLAYPGI
     KVSTAEARAI LPAQYRRQDC IAHGRHLAGF IHACYSRQPQ LAAALMKDVI AEPYRARLLP
     GFSQARQAVS EIGALASGIS GSGPTLFALC DKPETAQRVA DWLSKHYLQN QEGFVHICRL
     DTAGARVVG
//
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