ID CAIA_SALG2 Reviewed; 380 AA.
AC B5RGA6;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 1.
DT 01-MAY-2013, entry version 36.
DE RecName: Full=Crotonobetainyl-CoA dehydrogenase;
DE EC=1.3.99.-;
DE AltName: Full=Crotonobetainyl-CoA reductase;
GN Name=caiA; OrderedLocusNames=SG0076;
OS Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=550538;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=287/91 / NCTC 13346;
RX PubMed=18583645; DOI=10.1101/gr.077404.108;
RA Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K.,
RA Moule S., Mungall K., Saunders M., Whitehead S., Chabalgoity J.A.,
RA Maskell D., Humphreys T., Roberts M., Barrow P.A., Dougan G.,
RA Parkhill J.;
RT "Comparative genome analysis of Salmonella enteritidis PT4 and
RT Salmonella gallinarum 287/91 provides insights into evolutionary and
RT host adaptation pathways.";
RL Genome Res. 18:1624-1637(2008).
CC -!- FUNCTION: Catalyzes the reduction of crotonobetainyl-CoA to gamma-
CC butyrobetainyl-CoA (By similarity).
CC -!- COFACTOR: FAD (By similarity).
CC -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC -!- SUBUNIT: Homotetramer (By similarity).
CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
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DR EMBL; AM933173; CAR35983.1; -; Genomic_DNA.
DR RefSeq; YP_002225215.1; NC_011274.1.
DR ProteinModelPortal; B5RGA6; -.
DR STRING; 550538.SG0076; -.
DR EnsemblBacteria; CAR35983; CAR35983; SG0076.
DR GeneID; 6923211; -.
DR KEGG; seg:SG0076; -.
DR PATRIC; 18498238; VBISalEnt1629_0082.
DR eggNOG; NOG148174; -.
DR HOGENOM; HOG000131659; -.
DR KO; K08297; -.
DR OMA; YSAAIVW; -.
DR ProtClustDB; PRK03354; -.
DR BioCyc; SENT550538:GJ93-73-MONOMER; -.
DR UniPathway; UPA00117; -.
DR GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:HAMAP.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0009437; P:carnitine metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.540.10; -; 1.
DR Gene3D; 2.40.110.10; -; 1.
DR HAMAP; MF_01052; CaiA; 1; -.
DR InterPro; IPR006089; Acyl-CoA_DH_CS.
DR InterPro; IPR006092; Acyl-CoA_DH_N.
DR InterPro; IPR006090; Acyl-CoA_Oxase/DH_1.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR013786; AcylCoA_DH/ox_N.
DR InterPro; IPR009100; AcylCoA_DH/oxidase.
DR InterPro; IPR023450; Crotonobetainyl-CoA_DHase_CaiA.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR SUPFAM; SSF56645; AcylCoA_dehyd_NM; 1.
DR SUPFAM; SSF47203; AcylCoADH_C_like; 1.
DR PROSITE; PS00072; ACYL_COA_DH_1; 1.
DR PROSITE; PS00073; ACYL_COA_DH_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT CHAIN 1 380 Crotonobetainyl-CoA dehydrogenase.
FT /FTId=PRO_1000136281.
SQ SEQUENCE 380 AA; 42481 MW; 4A7A39798EDFC806 CRC64;
MDFNLNDEQE LFVAGIRELM ASENWEAYFA ECDRDSVYPE RFVKALADMG IDSLLIPEEH
GGLEAGFVTV AAVWMELGRL GAPTYVLYQL PGGFNTFLRE GTQEQIDKIM AFRGTGKQMW
NSAITEPGAG SDVGSLKTTY TRKNGKVYLN GSKCFITSSA YTPYIVVMAR DGASPDKPVY
TEWFVDMSKA GIKVNKLEKL GLRMDSCCEI TFDDVELDEK DMFGREGNGF NRVKEEFDHE
RFLVALTNYG TAMCAFEDAA RYANQRVQFG EAIGRFQLIQ EKFAHMAIKL NSMKNMLLEA
AWKADNGTIT SGDAAMCKYF CANAAFEVVD TAMQVLGGVG IAGNHRITRF WRDLRVDRVS
GGSDEMQILT LGRAVLKQYR
//
