ID B5RMI0_BORDL Unreviewed; 1147 AA.
AC B5RMI0;
DT 04-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 04-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=recB {ECO:0000313|EMBL:ACH93566.1};
GN OrderedLocusNames=BDU_637 {ECO:0000313|EMBL:ACH93566.1};
OS Borrelia duttonii (strain Ly).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC Borrelia.
OX NCBI_TaxID=412419 {ECO:0000313|EMBL:ACH93566.1, ECO:0000313|Proteomes:UP000000611};
RN [1] {ECO:0000313|EMBL:ACH93566.1, ECO:0000313|Proteomes:UP000000611}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ly {ECO:0000313|EMBL:ACH93566.1,
RC ECO:0000313|Proteomes:UP000000611};
RX PubMed=18787695; DOI=10.1371/journal.pgen.1000185;
RA Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J.,
RA Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.;
RT "The genome of Borrelia recurrentis, the agent of deadly louse-borne
RT relapsing fever, is a degraded subset of tick-borne Borrelia duttonii.";
RL PLoS Genet. 4:E1000185-E1000185(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP000976; ACH93566.1; -; Genomic_DNA.
DR AlphaFoldDB; B5RMI0; -.
DR STRING; 412419.BDU_637; -.
DR KEGG; bdu:BDU_637; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_008504_0_0_12; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000000611; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0008854; F:exodeoxyribonuclease V activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd22352; RecB_C-like; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR004586; RecB.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR00609; recB; 1.
DR PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..429
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 450..737
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 18..25
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1147 AA; 136081 MW; C15C9DFF0B177053 CRC64;
MKEIIDKIKN NDKILIEASA GTGKTYTLEH IITNLLTTTM YTPNEILVLT FTKKATEEMH
TRILKSIEHI YQNAKTDNLL KNIYEQSNKI FISTINKFAL YSLNNFQIET ENFSKYTVKE
NFTSEIDEII YEFLRKENSL KKELKIKDDE FEIFKSKFTN TKDMIQALRQ SYKRHKTEEL
GDWLEAQTTF KQILQNKERL LCNYNTIIDE LEEMSTEEKR TFLNKHNQGI KISEIEYSHA
TDIIHITEIL TNNKFLCKII EANLKKNVTL SPKELSIQTS LIQLSNETNT NKENKNTLKR
FVILKVEYKI LQYIEKELEN IINTTNVIDQ KHIMTNFKKH LESSEHKLLT SIKNRHKIIL
IDEAQDLDQT QIKIFELLNS CGIKIVFIAD PKQIIYTFRN ADISFYNQDI KDKIKKDARI
TLLTNYRSNK KLVKPLNIMF ERIYNKTHTD KIEQIEFVQL QTEPKNDNNK IFINDQEIKA
INIIQAEEND NVFQKTALIT KYLLINGKIY DNNQLRQIEK SDIKVLCRTS KEINFIDREL
KKNNIKTHKT KEPFFKTKEF NEIFYLVKCL SRKQDFKTLN YVLTSKMINL PWELHLNLIQ
NNKIKNIEEA ISDIIYLLEN QEITLMQAID EIISKQDLWI NLAKDLNNDE FTKFAQSKQN
YKENLINENK FEELQNYESS LNFILKTYYK DKNIESLICI LEDLILGRDI ENIEQYEEQT
NNDNQSIEIL TIHKSKGLGF NIVFLIGDTQ NNDTLIKKTD IFYKYYLNNK IKYDFLKLKE
NQQLAKNKIL NEEKNIFYVG TTRSKFALFI INQGTIINKM LRLAEINTID GINLNFNIPN
LNNYNQYNQS DINNDQQKAI TLIPPPPINK YLFRQEYIHS YTSLTSSYNT VNQNITDDET
YDNDAIHNKN TLPKGKDIGN ILHEIMKDIN FNDAKDSLSN FKKNNSMLIQ QKIEYFNSKL
NTPIIQELLI KMIYNMLNKK INFIDTKLCE IQELQKEMEF LIKINTKIYK QMSLFKQYNR
LDFMLNNGYI KGIIDLIFKI NNKIYILDYK TNYLGENLQD YRLSHLTKKM KQENYDLQYK
IYTLGIKKIL FKNKEEYEKH FGGVIYLFTR AFQEDIQTQD QIQNGIYSTI PNFQEIELEQ
IYLQLKH
//
