ID B5TF06_HBV Unreviewed; 394 AA.
AC B5TF06;
DT 04-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 04-NOV-2008, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ACH81302.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACH81302.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ACH81302.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HBVAB32 {ECO:0000313|EMBL:ACH81302.1};
RX PubMed=18715605; DOI=10.1016/j.virol.2008.07.009;
RA Zehender G., Maddalena C.D., Giambelli C., Milazzo L., Schiavini M.,
RA Bruno R., Tanzi E., Galli M.;
RT "Different evolutionary rates and epidemic growth of hepatitis B virus
RT genotypes A and D.";
RL Virology 380:84-90(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; EU908790; ACH81302.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACH81302.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:ACH81302.1"
SQ SEQUENCE 394 AA; 44212 MW; AE1A6A527AB7F634 CRC64;
GSIRARAHPS TRRYFGVEPS GSGHIDHSVN NSSSCLHQSA VRKAAYSHLS TSKRQSSSGH
AVEFHCLPPS SAGSQSQGSV FSCWWLQFRN SKPCSEYCLS HLVNLREDWG PCDEHGEHHI
RIPRTPARVT GGVFLVDKNP HNTAESRLVV DFSQFSRGIT RVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHIPLH PAAMPHLLIG SSGLSRYVAR LSSNSRINNN QYGTMQNLHD
SCSRQLYVSL MLLYKTYGWK LHLYSHPIVL GFRKIPMGVG LSPFLLAQFT SAICSVVRRA
FPHCLAFSYM DDVVLGAKSV QHRESLYTAV TNFLLSLGIH LNPNKTKRWG YSLNFMGYII
GSWGTLPQDH IVQKIKHCFR KLPVNRPIDW KVCQ
//
