ID B5U9W5_ONCMY Unreviewed; 2488 AA.
AC B5U9W5;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
GN Name=notch1 {ECO:0000313|EMBL:BAG71913.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:BAG71913.1};
RN [1] {ECO:0000313|EMBL:BAG71913.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18646050; DOI=10.1002/mrd.20947;
RA Yano A., von Schalburg K., Cooper G., Koop B.F., Yoshizaki G.;
RT "Identification of a molecular marker for type A spermatogonia by
RT microarray analysis using gonadal cells from pvasa-GFP transgenic rainbow
RT trout (Oncorhynchus mykiss).";
RL Mol. Reprod. Dev. 76:246-254(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AB430584; BAG71913.1; -; mRNA.
DR RefSeq; NP_001129167.1; NM_001135695.1.
DR GeneID; 100190917; -.
DR KEGG; omy:100190917; -.
DR CTD; 4851; -.
DR OrthoDB; 5473534at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 28.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 35.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF411; SUSHI, NIDOGEN AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 18.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 32.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 15.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 23.
DR PROSITE; PS00022; EGF_1; 33.
DR PROSITE; PS01186; EGF_2; 27.
DR PROSITE; PS50026; EGF_3; 36.
DR PROSITE; PS01187; EGF_CA; 10.
DR PROSITE; PS50258; LNR; 3.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2488
FT /note="Neurogenic locus notch homolog protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002836472"
FT TRANSMEM 1737..1758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..58
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 59..99
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 102..139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 140..176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 178..216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 218..255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 257..293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 372..410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 412..450
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 452..488
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 490..526
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 528..564
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 566..601
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 603..639
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 641..676
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 678..714
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 716..751
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 753..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 791..827
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 829..868
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 870..906
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 908..944
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 946..982
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 984..1020
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1022..1058
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1060..1096
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1109..1144
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1146..1182
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1184..1220
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1222..1266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1268..1306
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1308..1347
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1349..1385
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1388..1426
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1450..1490
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1491..1528
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1529..1572
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1930..1962
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1997..2029
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2030..2062
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2063..2095
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 2149..2190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2206..2270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2337..2369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2415..2488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2162..2185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2214..2236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2415..2439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2447..2488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 432
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 435
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 452
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 453
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 455
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 469
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 470
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 490
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 491
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 493
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 507
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 48..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 89..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 129..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 166..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 206..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 245..254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 283..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 361..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 381..398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 400..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 416..429
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 423..438
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 440..449
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 456..467
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 461..476
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 478..487
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 494..505
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 499..514
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 516..525
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 554..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 570..580
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 591..600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 629..638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 645..655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 666..675
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 704..713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 720..730
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 741..750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 779..788
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 817..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 839..856
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 858..867
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 896..905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 934..943
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 972..981
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1010..1019
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1048..1057
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1086..1095
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1134..1143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1172..1181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1210..1219
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1256..1265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1277..1294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1296..1305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1337..1346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1375..1384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1397..1414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1416..1425
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2488 AA; 269333 MW; 66A58D153C683977 CRC64;
MYRFFVKLTF LIPVIVITQG LRCSLTTESC LNGGRCEASS DRNGECRCTS DYVGSRCQYS
NPCNPSPCRN GGECRAVSHG NTFEFHCKCR LGFSDQLCLT PTNHACMSSP CRNGGTCDLI
TLSDYRCRCP PGWSGKTCQI ANPCASNPCA NGGQCSPFES HYICACLPAF HGQTCKLDVN
ECAQMSSPCR NGGMCVNEVG SYHCRCPQEY TGANCETPYM PCNPSPCHSG GTCVQKGDTT
YDCSCLPGFT SQNCDHNIDD CPGHNCQNGG LCVDGVNTYN CQCPPHFTGQ FCTENVDECE
MMPNTCQNGG TCHDTYGSFH CVCVNGWTGD DCSENIDDCA SAACYHGATC HDRVASFFCE
CPHGRTGLLC HLDDACISNP CQKGSNCDTN PVNGKAICTC PPGYTGSACN QDIDECSLGA
NPCEHGGRCL NTKGSFQCKC LQGYEGPRCE MDVNECMSNP CQNDATCLDQ IGGFHCICMS
GYEGMFCQIN TDECASMPCL NNGKCIDRIN SFHCECHKGF SGGLCQVDID ECASTPCMNG
AKCTDGPNKY SCECTEGYSG PHCETDINEC YSDPCHYGTC KDGLATFTCY CHPGYTGRLC
ETNINECLSQ PCQNGGTCQD RENTYICTCP KGTAGFNCEV NLDDCKSKPC DYGRCIDKIN
SYECACEPGY AGAMCNINTD ECAINPCHNG GTCIDGINSF TCLCPEGYSD ATCLLQVNEC
GSNPCIHGRC QDLLNGYRCF CDSGWGGPNC DINNNECESN PCMNGGTCKD MTSGYVCSCR
AGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGEMCETLL APCSPMQPCK
NGGVCHESED YHSFSCLCPE GWQGQTCEID INECVKSPCR SGATCHNMVG SYRCSCRPGY
TGQKCETDID NCKPNPCSNG GLCRDGVDSF VCTCLPGFRG GRCEHDINEC ESNPCKNGAN
CTDCVNSYTC TCQPGFSGIN CENNTPDCTE SSCFNGGTCV DGINTFTCLC LPGFTGSYCQ
HDINECDSKP CLNGGTCLDS YGTYKCTCSH GYTGVNCQNL VRWCDSSPCK NGGSCWQQGS
SYTCQCQTGW TGLYCDVPSV SCEVAAKQQG VEVAHLCRNS GQCLDAGNTH YCRCQAGYMG
SYCQEQVDEC SPNPCQNGAT CTDYLGGYSC ECLPGYHGVN CSKEINECLS QPCQHGGTCI
DLINTYKCSC PRGTQGIHCE INLDDCNPST DPLTYESKCF NKGQCVDRVG GYHCMCPAGY
VGERCEGDVN ECLSDPCDLR GSYNCVQLTN SYRCECRTGY TGQRCDKVFD GCKGRPCRNG
GMCAVASNNP DGFICKCPPG YTGSSCEYDS RFCGSLNCRN GGTCVSGHLS PRCLCPTAFT
GPECQTPTNS PCNVNHCYNG GTCQRTPDAP FFHCSCPNNF NGLLCHILDY SFPGGFGRDI
TPPPEVEVSC EIPQCDEWAG NHICDSLCNN HACGWDGGDC SLNFDDPWQN CSAALQCWRY
FNDGKCDEQC KSPGCLYDGF DCQGQEGQCN PLYDQYCKDH YADGHCDQGC NNAECEWDGL
DCANNMPEKL ADGHLVLVVH IPPEQLKNGL STFLRELSSV LHTNVVFRRD ANGEPMVFPY
YGSEQELAKH NVKRSTDSWP DWAVVPANML GQMKESVGSM VNLPRQRREL DLMQVKGSVV
YLEIDNRQCY QQSTGCFQSA TDVAAFLGAL ASSGNLNVPY IEAVTSVQPT RASSELYPMY
VVFLGLAVLG FICLGVLVSR KRRREHGQLW FPEGFKVSEP SKKKRREPVG EDSVGLKPLK
NILDISLMDD SQNGLWGEEE PDSRRFRFEE QAVLNLDDRT DHRQWTQQHL DAADLRIPSI
APTPPQGEIE NDCMDVNVRG PDGFTPLMIA SCSGGGLETG NSEEEEDPSA EIISDFIYQG
ANLHNQTDRT GETALHLAAR YARSDAAKRL LESTADANVQ DNMGRTPLHA AVAADAQGVF
QILIRNRATD LDARMHDGTT PLILAARLAV EGMVDELINC HADANAIDDF GKSALHWASA
VNNVDAAMVL LKNGANKDMQ NNKEETPLFL AAREGSYETA KVLLEHFANR EITDHLDQLP
RDIAQERMHH DIIRLLDEYN LVRSPGLHNG TLSATNLSPP LCSPNGYLGS LKPTAPGKKV
RKPGSGGKDG GKDMRIRKKK SLDGKGSLLD SSAVLSPVDS LESPHGYLSD VASPPMTSPF
QQSPPMSFNH LQGSGDSHVG QMGMGKGQDM GRMPFDPNPP RLSHLPVSSP GSQGTITMAM
DGAGGRGQCD WHSRIHPGLG QQGGFNQGLP MSHGMMAPLR GVPTATLSRI MGYQGLQTSH
LGTPPHLMQQ MHSRQNPQLQ HQNSNSTTAG QVLSQSFLSS ELSGSDLQQG NGVGRSVPIH
TILPQETQIL GTQFLTPPSQ HSYSGPIDNT PNHQLQVPDH PFLTPSPGSP DQWSSSSPNS
NMSDWSEGIS SPPMSLHSQM GLIPNQFK
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