ID B5X0I3_STIAD Unreviewed; 1837 AA.
AC B5X0I3;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=CrpB-like protein {ECO:0000313|EMBL:ADO72614.1};
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:CAQ34920.1};
GN Name=dkxI {ECO:0000313|EMBL:CAQ34920.1};
GN OrderedLocusNames=STAUR_4836 {ECO:0000313|EMBL:ADO72614.1};
OS Stigmatella aurantiaca (strain DW4/3-1).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Archangiaceae; Stigmatella.
OX NCBI_TaxID=378806 {ECO:0000313|EMBL:CAQ34920.1};
RN [1] {ECO:0000313|EMBL:CAQ34920.1}
RP NUCLEOTIDE SEQUENCE.
RA Meiser P., Weissman K.J., Bode H.B., Krug D., Dickschat J.S., Sandmann A.,
RA Bode H.B., Mueller R.;
RT "DKxanthene Biosynthesis - Understanding the Basis for Diversity-Oriented
RT Synthesis in Myxobacterial Secondary Metabolism.";
RL Chem. Biol. 15:771-781(2008).
RN [2] {ECO:0000313|EMBL:ADO72614.1, ECO:0000313|Proteomes:UP000001351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DW4/3-1 {ECO:0000313|EMBL:ADO72614.1,
RC ECO:0000313|Proteomes:UP000001351};
RX PubMed=21037205; DOI=10.1093/molbev/msq292;
RA Huntley S., Hamann N., Wegener-Feldbrugge S., Treuner-Lange A., Kube M.,
RA Reinhardt R., Klages S., Muller R., Ronning C.M., Nierman W.C.,
RA Sogaard-Andersen L.;
RT "Comparative genomic analysis of fruiting body formation in Myxococcales.";
RL Mol. Biol. Evol. 28:1083-1097(2011).
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DR EMBL; CP002271; ADO72614.1; -; Genomic_DNA.
DR EMBL; BN001209; CAQ34920.1; -; Genomic_DNA.
DR RefSeq; WP_013376467.1; NZ_AAMD01000058.1.
DR STRING; 378806.STAUR_4836; -.
DR KEGG; sur:STAUR_4836; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_31_5_7; -.
DR OrthoDB; 5478077at2; -.
DR Proteomes; UP000001351; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR049490; C883_1060-like_KR_N.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF21394; Beta-ketacyl_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 32..455
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1740..1816
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1837 AA; 199231 MW; FEE43A08266002B9 CRC64;
MAKLSTRLSE MPPVKLAYLA SQLRAKKEIL AAEPIAVIGM SCRFPGGGER PETFWEFLKG
AGDATREVPR ERWDIDEIYD PTPGVRGKVY TRRGAFIEDV DLFDPGFFGI PPRDAKDMDP
QQRLLHEECW RALERAGIPP AGLVGSRTGV FVGLMHNDYN VLGITSGVEM FAASLNYPSM
AAGRIAHTLG FQGPALTVDT ACSSSAVCIH LACQSLRNDE SDLALAGGVS LSLSPITMMF
GCENRMLSVD GRCKTFDASA DGFARGEGCG VVVLKRLSDA LAKGDPILGI IRGSAVNHDG
RSSGLMVPNG RAQERVIRMA LDGCGVEPHQ ISYVEAHGTG TALGDPIEME AIRSVFGRKT
TRSEPLLVGS VKTNIGHLEA AAGVSGLIKV ILSLQNEIIP AHLNFERPNP NIRWDDLPVI
IPTSMRPWPR GEKRRIAGVS SFGFSGTNAH LIVEEAPLTA RPPLEKERPI HVLTMSAKTD
ASLDALVEAH ERALPNDDAS LGDWCYTANV GRSHFEHRLA VSGATSASLR AGLARLRAEK
LRPDREPRQG TESPKPVFLF TGQGALQPGV GRELYETQPA FRAALQRCSS VLESKLGLRL
ENLLFGEEAP ALLEDTRNAQ PVLVALEYAL SELWASWGVI PGALVGHSLG EYAAAAVAGV
MSIEDALGLS VERARLMSAA PGEGAMLAIS ASQEVTAQAI EPYPGVVSFA AINGPEDMVV
SGGKSALEAL KGDLERRGIH CKFLRVPHAF HSPLMDPVLG PFAEVLKGVK LSVPHIPFVS
TLEGRPVTDP LTQPEYWCRH LREPVHFAKG LGFLREQGHR TYLELGPAPI LAGIGRRLFP
EAEELCWLPS LRPSEGETAQ MLSSLSALYV RGFEVDWAAF DAPFERRTRD LPTYPFQRDR
YWIEAQNTGS LQYMTDRGTS KDAAHPLAGV ALSLAGSKET RFAARLSIRE PAFIAEHRIL
GMTVLPAACY VEMALGAVYH ADSRERPIEL KAIELERPLV FTEAEGCDVQ TVLTPEEANS
RFEIYAQGAG SERRWARLAQ GRVEEGSGWA GRIDLKAELF ERFPQQGSVV ALYELMDRSG
LEYGPSFRAI HELRFGENGC LAHVRLPDSL IVGLDSYRLH PLILDACFQA VAAVFMEDDA
QFKGERRQRM PVAIERLRWF KKAGSSVWVH VQRNSRSSTS AEVLSASLRI LGEDGEVIAE
VDGLLLKQVD RNAFKASFAD STRELLFELA WREQRASQER DRVVSPPGHW LLFADSGSVA
ERLKELVLQH SRTCVTVSPG AGYEKLGRDH YRLDPADPAG FDRLFQDLSA GGVAPATVAY
LWGLDERGAA ELSAEELAGV TARSSAGALH LVQAMARVAW AQRPALWMVT RGAVAAVPSD
GVGGLSQTPI WGLGRAAAIE HPELGCRLAD LDGDEGAPAR LFQLMAEPPE ENMMALRGSQ
LLGARLVRPD KAVSRSSPVR IRSDGTYLLT GGMGALGLAT AEWLVEEGAR QLVLVGRGEP
GEAVKARINA LTARGCHVTV TRADVSRREE VQRLVEGISA RESQLLGIFH IAGVLDDGVF
MLQSRERIAQ VFVPKVLGAW NLHLATAQLP LDLFVMYSSA ASLVGVAGQA NYVAANSFLD
ALAYHRSRQG LPALSVNWGR WSGEGMAAKT SAKGSTQGVD AGNLSPRRAL QILGDLLMLD
VVQMGVVSFA VAAVDSALSP GHGPLFSELM MREQARSSSV ARMHELLGEL KSADSVRRRG
LLTHYVQGRM APLLGFAPDH EVFQKKVSLN EMGLDSLRAV ELKNRIGREL GVDLPMARFI
DGTNLEGIVE ALHSQLELNE LLARPPSAAV EIEELTL
//
