ID B5X3J5_SALSA Unreviewed; 489 AA.
AC B5X3J5;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Glutaredoxin {ECO:0000313|EMBL:ACI33876.1, ECO:0000313|RefSeq:NP_001133773.1};
DE EC=1.8.4.1 {ECO:0000313|RefSeq:NP_001133773.1};
DE SubName: Full=Glutaredoxin-1 isoform X2 {ECO:0000313|RefSeq:XP_014029439.1, ECO:0000313|RefSeq:XP_014029440.1};
GN Name=GLRX {ECO:0000313|EMBL:ACI33876.1};
GN Synonyms=glrx {ECO:0000313|RefSeq:NP_001133773.1,
GN ECO:0000313|RefSeq:XP_014029439.1, ECO:0000313|RefSeq:XP_014029440.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI33876.1};
RN [1] {ECO:0000313|EMBL:ACI33876.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33876.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI33876.1, ECO:0000313|RefSeq:NP_001133773.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33876.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI33876.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33876.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001133773.1, ECO:0000313|RefSeq:XP_014029439.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014029439.1,
RC ECO:0000313|RefSeq:XP_014029440.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the
CC presence of NADPH and glutathione reductase. Reduces low molecular
CC weight disulfides and proteins. {ECO:0000256|ARBA:ARBA00002549}.
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DR EMBL; BT045614; ACI33876.1; -; mRNA.
DR RefSeq; NP_001133773.1; NM_001140301.1.
DR RefSeq; XP_014029439.1; XM_014173964.1.
DR RefSeq; XP_014029440.1; XM_014173965.1.
DR STRING; 8030.ENSSSAP00000066466; -.
DR PaxDb; 8030-ENSSSAP00000066466; -.
DR GeneID; 100195272; -.
DR KEGG; sasa:100195272; -.
DR OMA; IVVSQCH; -.
DR OrthoDB; 1216362at2759; -.
DR Proteomes; UP000087266; Chromosome ssa25.
DR Bgee; ENSSSAG00000059573; Expressed in head kidney and 15 other cell types or tissues.
DR GO; GO:0047139; F:glutathione-homocystine transhydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd04371; DEP; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR006869; DUF547.
DR InterPro; IPR011767; GLR_AS.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR014025; Glutaredoxin_subgr.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR34386; GLUTAREDOXIN; 1.
DR PANTHER; PTHR34386:SF1; GLUTAREDOXIN-LIKE PROTEIN NRDH; 1.
DR Pfam; PF04784; DUF547; 1.
DR Pfam; PF00462; Glutaredoxin; 1.
DR PRINTS; PR00160; GLUTAREDOXIN.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Redox-active center {ECO:0000256|ARBA:ARBA00023284};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 12..71
FT /note="Glutaredoxin"
FT /evidence="ECO:0000259|Pfam:PF00462"
FT DOMAIN 287..413
FT /note="DUF547"
FT /evidence="ECO:0000259|Pfam:PF04784"
FT REGION 99..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 54475 MW; 6E3DCB63042AE638 CRC64;
MGETEGRVLG RVTVYSVLGC PHCVQAKTSL GRLGLPVWDV DMGKHPELRG SVKELTGRST
VPQIFFNSVH IGGNDDLQEL LPEELERLVR LVREEPVLPE ALPLPEENQS DGSDTAEEAD
GEFKCERDAL ANVVEDLKRS DVIGFQWRGL SMCRNSFTGA QLVGWLQKDR GMEMTKACET
GQVLLDRKYM VGVAGAGKGE GFGVSDRLYR LMEHNPHSAL NAGQTAACSP LQTAELSAIL
RDMILKLFSE YLSSDGKCVD YKAMSLSPVF ERYCELAVQL QRVELLSLTR EEKLAFFINT
YNALVIHGNV RMGAPTNMWQ RYKFFNYVSY LIGGEVFTLQ DIENGVLRGN RKGVAQLLRP
FSKTDPRLQV ALPDAEPLIH FALNCGAMGC PPIKTYTPQD IDSQLRTAAE SFLENDDGCV
VDSEKGEVRL SQIFKWYKAD FGGTDEKLLN WILEHMGESP KRSSLQSVLS SGKIKVSYLP
YDWSTNSSH
//
