ID B5X458_SALSA Unreviewed; 523 AA.
AC B5X458;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Lens epithelium-derived growth factor {ECO:0000313|EMBL:ACI34089.1};
DE SubName: Full=PC4 and SFRS1 interacting protein 1 {ECO:0000313|RefSeq:NP_001133892.1};
GN Name=PSIP1 {ECO:0000313|EMBL:ACI34089.1};
GN Synonyms=psip1 {ECO:0000313|RefSeq:NP_001133892.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI34089.1};
RN [1] {ECO:0000313|EMBL:ACI34089.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI34089.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI34089.1, ECO:0000313|RefSeq:NP_001133892.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI34089.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI34089.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI34089.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001133892.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HDGF family.
CC {ECO:0000256|ARBA:ARBA00005309}.
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DR EMBL; BT045827; ACI34089.1; -; mRNA.
DR RefSeq; NP_001133892.1; NM_001140420.1.
DR STRING; 8030.ENSSSAP00000039381; -.
DR PaxDb; 8030-ENSSSAP00000039381; -.
DR GeneID; 100195391; -.
DR KEGG; sasa:100195391; -.
DR CTD; 11168; -.
DR OrthoDB; 4271850at2759; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd20151; PWWP_PSIP; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR021567; LEDGF_IBD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR PANTHER; PTHR12550; HEPATOMA-DERIVED GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR12550:SF42; PC4 AND SFRS1-INTERACTING PROTEIN; 1.
DR Pfam; PF11467; LEDGF; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF140576; HIV integrase-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 7..64
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 99..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 59346 MW; D594B1D765E1408E CRC64;
MARDYKPGDL IFAKMKGYPH WPARINDYSD GAVKPANMKF PIFFFGTHET AFLGPKDIYP
YLPNKEKYAK PNKRKGFNEG LWEVENNPKV ELNGETQMML SDNVTEKDSD SNPEGDEEGD
YEKRKKPKVS GAESEAGQEE DGGMQVSEQG QPQGQDDPTP KESTDTPKPK RRRKKKSDVE
ADSEKEDAAN SPTSSPQGGE GPTPKRRGRK TKAEKMLLLQ QQDPQGSGSD MDTAESERKR
KRTPEDKSKR GEEEKRLDGR RKKEDNKGRE LEGKKDPDAK RRRQTKEESS SDSEDQEKSK
GAAGDRKRQQ PTPTETGDKD DRQRRKQDEQ KEQNKDNGNK VDERKGDKKK EISTESRLQR
LHGEIKISLK IDNPDVKKCL VALDELGMLQ VTTQHLQKHS ELIATLKKIR RFKASQDIMD
KSTMLYNKFK SMFLLGEGDQ LLSQVLNKSI AEQKQQEEAR KGAQRKAERA RENNTDNNMN
GDSSPDDKKQ ESDKEKPAEE ASTGDNSSEG PRGIHLMKKH LTD
//
