ID B5XAW6_SALSA Unreviewed; 320 AA.
AC B5XAW6;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=NF-kappa-B inhibitor alpha {ECO:0000256|ARBA:ARBA00041123};
DE AltName: Full=I-kappa-B-alpha {ECO:0000256|ARBA:ARBA00041987};
GN Name=IKBA {ECO:0000313|EMBL:ACI67986.1};
GN Synonyms=LOC106611175 {ECO:0000313|RefSeq:XP_014066592.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI67986.1};
RN [1] {ECO:0000313|EMBL:ACI67986.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN12590.1}, and Thyroid
RC {ECO:0000313|EMBL:ACI67986.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACN10235.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed brain {ECO:0000313|EMBL:ACN10235.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar full-length cDNAs.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ACI67986.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN12590.1}, and Thyroid
RC {ECO:0000313|EMBL:ACI67986.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [4] {ECO:0000313|EMBL:ACI67986.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN12590.1}, and Thyroid
RC {ECO:0000313|EMBL:ACI67986.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|RefSeq:XP_014066592.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014066592.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
CC {ECO:0000256|ARBA:ARBA00038439}.
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DR EMBL; BT048185; ACI67986.1; -; mRNA.
DR EMBL; BT058522; ACN10235.1; -; mRNA.
DR EMBL; BT060230; ACN12590.1; -; mRNA.
DR RefSeq; XP_014066592.1; XM_014211117.1.
DR STRING; 8030.ENSSSAP00000049801; -.
DR PaxDb; 8030-ENSSSAP00000049801; -.
DR Ensembl; ENSSSAT00000077743; ENSSSAP00000049801; ENSSSAG00000049805.
DR GeneID; 106611175; -.
DR KEGG; sasa:106611175; -.
DR CTD; 323099; -.
DR OMA; EIRIQPQ; -.
DR OrthoDB; 621606at2759; -.
DR Proteomes; UP000087266; Chromosome ssa09.
DR Bgee; ENSSSAG00000049805; Expressed in spleen and 16 other cell types or tissues.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR PANTHER; PTHR46680:SF1; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 116..148
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 189..221
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 223..255
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 286..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 35842 MW; 4584FD8CFB1574F6 CRC64;
MDLHRTRILN HMDCNTDGRH SKDGKVKSFN EERLDSGLDS LKDEEYKVVA CELERLRVDC
PPPQRDECGN EPWKEQVSED GDTLLHLAII HEAKDCARKM IELSCNEPFL NQHNYQRQTP
LHLAVITEQA EIVERLLKAG CDPTLVDDSG NTALHIACRK GSLTCFSVLT QTQGCSTQLP
AIMATPNYSG QNCLHLVSIH GFLSLVESLV DLGADIDAQE QCNGRSPLHL AVDLQNLDLV
LLLVSKGANV NSLTYGGHTP YHLTYGRQNA SIERELYELT AQELRELPDS ESEDSEEEEG
QSDDEVVTCW YDDVQWNGCH
//
