ID B5XD08_SALSA Unreviewed; 320 AA.
AC B5XD08;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Signal transducer and activator of transcription 1 {ECO:0000313|EMBL:ACI68728.1, ECO:0000313|RefSeq:NP_001134757.1};
GN Name=STAT1 {ECO:0000313|EMBL:ACI68728.1};
GN Synonyms=stat1 {ECO:0000313|RefSeq:NP_001134757.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI68728.1};
RN [1] {ECO:0000313|EMBL:ACI68728.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACI68728.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI68728.1, ECO:0000313|RefSeq:NP_001134757.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACI68728.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|RefSeq:NP_001134757.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20353564;
RA Skjesol A., Hansen T., Shi C.Y., Thim H.L., Jorgensen J.B.;
RT "Structural and functional studies of STAT1 from Atlantic salmon (Salmo
RT salar).";
RL BMC Immunol. 11:17-17(2010).
RN [4] {ECO:0000313|EMBL:ACI68728.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACI68728.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|RefSeq:NP_001134757.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BT048927; ACI68728.1; -; mRNA.
DR RefSeq; NP_001134757.1; NM_001141285.1.
DR STRING; 8030.ENSSSAP00000054109; -.
DR PaxDb; 8030-ENSSSAP00000054109; -.
DR GeneID; 100196256; -.
DR KEGG; sasa:100196256; -.
DR CTD; 368481; -.
DR OrthoDB; 4251387at2759; -.
DR Proteomes; UP000087266; Chromosome ssa21.
DR GO; GO:0005737; C:cytoplasm; IMP:AgBase.
DR GO; GO:0005634; C:nucleus; IMP:AgBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0097678; F:SOCS family protein binding; IMP:AgBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16851; STAT1_CCD; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF18; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA_BETA; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02865; STAT_int; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999}.
FT DOMAIN 2..122
FT /note="STAT transcription factor protein interaction"
FT /evidence="ECO:0000259|SMART:SM00964"
FT COILED 131..200
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 320 AA; 37629 MW; 183929D384D2B808 CRC64;
MAQWFQLQQL DSKYLEQVDQ LYDDTFPMEI RQYLSAWIES HDWDMVATSV SLAAVRFHDL
LAQLDIQYSR FALENNFLLQ HNIRKIKRNL QDHFQEYPLQ MAMIICNCLK EEKKILASII
KKEDNVGSTP NNMVLDKQKE LDNNVKDLRN RVQDAEHEIK SLEDLQDEHD FKKKTLQSRV
EQEVNGMAQL QAVRKEIREE EIVIRKMFIK LNITRGVVVN QISDILCLAE QIQFNLVTVE
VPEWKHRQQI ACIGGPPNAC LDQLQIWFTA VAEGLQQVRQ QLKKLQELEQ KYTYENDPIT
QGKSALEERA LTLFKYLIVK
//
