ID B5XT36_KLEP3 Unreviewed; 723 AA.
AC B5XT36;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Tyrosine-protein kinase Etk {ECO:0000313|EMBL:ACI11276.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:ACI11276.1};
GN Name=etk {ECO:0000313|EMBL:ACI11276.1};
GN OrderedLocusNames=KPK_1656 {ECO:0000313|EMBL:ACI11276.1};
OS Klebsiella pneumoniae (strain 342).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=507522 {ECO:0000313|EMBL:ACI11276.1, ECO:0000313|Proteomes:UP000001734};
RN [1] {ECO:0000313|EMBL:ACI11276.1, ECO:0000313|Proteomes:UP000001734}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=342 {ECO:0000313|EMBL:ACI11276.1,
RC ECO:0000313|Proteomes:UP000001734};
RX PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA Khouri H., Roesch L.F., Krogfelt K.A., Struve C., Triplett E.W.,
RA Methe B.A.;
RT "Complete genome sequence of the N2-fixing broad host range endophyte
RT Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL PLoS Genet. 4:E1000141-E1000141(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP000964; ACI11276.1; -; Genomic_DNA.
DR AlphaFoldDB; B5XT36; -.
DR KEGG; kpe:KPK_1656; -.
DR HOGENOM; CLU_009912_0_0_6; -.
DR Proteomes; UP000001734; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACI11276.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACI11276.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 32..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..106
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 365..444
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 539..652
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 252..300
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 723 AA; 80325 MW; 6E99D30B6239D8EA CRC64;
MAPISYKKQE QSEADELDLG RLVGEFIDHR KLILSVTIFF TVIALLYAMF STPIYQADAL
VQVEQKQGNA LLDSLNQVLP TGTQQSAPEI ALLQSRMVLG KTVDDLNLEI TIQKDYFPVF
GRGWARLTGT EGGNIKVSKL LLKKNDIENV KLEVIDEHNF IVTTSAGEIK GKVGTLIDNN
EFTIKVDEIN ADKGSSFTIQ KITRLQAINN LLKVFSVTDQ GKDTGMLNLT LVGEDPNQIT
DILNTISDNY LAQNISRQAA QDEKSLEFLK AQLPKVRDEL DDAENKLNAY RRKKDSVDLT
MEAQAVLNQI VNVDNQLNEL TFREAEISQL FTTDHPTYKA LLEKKKTLAQ EKVRLNNQVT
SMPTTQQEIL RLSRDVESGR AVYMQLLNRQ QELNISKSST IGNVRIVDSA IAEPKPVKPK
KIMVVLIGLV FGLFVSVGIV LARMFLRRGI ESPEELEDMG INVYASVPVS EWLTQKHFKN
GKRLAAKDVF KEDRESLLAL ENPADLAIEA IRSLRTSLHF AMLESSNNIL MISGASPNAG
KSFISSNLGA IVAQTGKRVL LIDADMRKGY IHKVFGVSNS NGISEILSGK STVGSAILNT
QLDNLDIITR GQVPPNPSEL LMHERLKLFL ESVSKEYDLI LVDTPPILAV TDAAIIGQYV
GTVLLVARFE LNTAKEIEIS KRRFEQSGIP VKGCILNGVV KKASSYYGYG YNHYGYSYNT
DKK
//
