ID B5Y038_KLEP3 Unreviewed; 359 AA.
AC B5Y038;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ACI10493.1};
GN OrderedLocusNames=KPK_4025 {ECO:0000313|EMBL:ACI10493.1};
OS Klebsiella pneumoniae (strain 342).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=507522 {ECO:0000313|EMBL:ACI10493.1, ECO:0000313|Proteomes:UP000001734};
RN [1] {ECO:0000313|EMBL:ACI10493.1, ECO:0000313|Proteomes:UP000001734}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=342 {ECO:0000313|EMBL:ACI10493.1,
RC ECO:0000313|Proteomes:UP000001734};
RX PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA Khouri H., Roesch L.F., Krogfelt K.A., Struve C., Triplett E.W.,
RA Methe B.A.;
RT "Complete genome sequence of the N2-fixing broad host range endophyte
RT Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL PLoS Genet. 4:E1000141-E1000141(2008).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000964; ACI10493.1; -; Genomic_DNA.
DR AlphaFoldDB; B5Y038; -.
DR KEGG; kpe:KPK_4025; -.
DR HOGENOM; CLU_018816_2_0_6; -.
DR BioCyc; KPNE507522:GI0B-4007-MONOMER; -.
DR Proteomes; UP000001734; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..359
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002838274"
FT DOMAIN 55..101
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 110..273
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 94..121
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 359 AA; 38825 MW; 26D54543588A75E7 CRC64;
MIKTFRFALL ACGLASGALT ATAAPAVPVR VATVELAPHA EERAIPGRVE AIRAVDIRAR
TEGVIVKRHF QDGQYVTEGD LLFTLDDAQP RAALALAQAE LKSAEASLRQ SQQLLTRYER
LINNHSISRN DVDTARMQRD VAAAAVQQAK ARVEAQQIVL SYTRIAAPVT GRVGHSAFHV
GTLINPSSGV LVDIVQLDPV RVSFALDEAA FFSKSGQHAD IHALKQAWLA QIDVDGKRRD
GVLTSIDNRI DARTGSVAVR AEFANPQHRL LPGGSVTILF RPQELQSRVM IPAAAVQQDP
QGFFSWVLKP DHTAGQRRLT LAGQQGQQFA VEKGLQAGEQ VITDGAQRLR EGAAVQVLN
//
