ID B5Y453_PHATC Unreviewed; 323 AA.
AC B5Y453;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Dihydropteridine reductase {ECO:0000256|ARBA:ARBA00039520};
DE EC=1.5.1.34 {ECO:0000256|ARBA:ARBA00039153};
DE AltName: Full=Quinoid dihydropteridine reductase {ECO:0000256|ARBA:ARBA00041348};
GN ORFNames=PHATR_21181 {ECO:0000313|EMBL:ACI65250.1};
OS Phaeodactylum tricornutum (strain CCAP 1055/1).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Naviculales; Phaeodactylaceae;
OC Phaeodactylum.
OX NCBI_TaxID=556484 {ECO:0000313|EMBL:ACI65250.1, ECO:0000313|Proteomes:UP000000759};
RN [1] {ECO:0000313|EMBL:ACI65250.1, ECO:0000313|Proteomes:UP000000759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCAP 1055/1 {ECO:0000313|EMBL:ACI65250.1,
RC ECO:0000313|Proteomes:UP000000759};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [2] {ECO:0000313|Proteomes:UP000000759}
RP GENOME REANNOTATION.
RC STRAIN=CCAP 1055/1 {ECO:0000313|Proteomes:UP000000759};
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA Lindquist E., Shapiro H., Lucas S., Glavina del Rio T., Pitluck S.,
RA Rokhsar D., Bowler C.;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; CP001141; ACI65250.1; -; Genomic_DNA.
DR RefSeq; XP_002185780.1; XM_002185744.1.
DR AlphaFoldDB; B5Y453; -.
DR STRING; 556484.B5Y453; -.
DR PaxDb; 2850-Phatr21181; -.
DR GeneID; 7204444; -.
DR KEGG; pti:PHATR_21181; -.
DR eggNOG; KOG4022; Eukaryota.
DR HOGENOM; CLU_010194_22_0_1; -.
DR InParanoid; B5Y453; -.
DR OrthoDB; 276282at2759; -.
DR Proteomes; UP000000759; Chromosome 11.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR15104; DIHYDROPTERIDINE REDUCTASE; 1.
DR PANTHER; PTHR15104:SF0; DIHYDROPTERIDINE REDUCTASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000759};
KW Tetrahydrobiopterin biosynthesis {ECO:0000256|ARBA:ARBA00023007}.
FT REGION 29..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 34515 MW; 536DC7F74D284F39 CRC64;
MLTLARKALP SKYSSFRVFG RGLGLPPAES IDQLPRPASQ SLSFSSYPGD EDDDDVGRPK
TALVLGSSGA LGSAVSHYLS QTVGMKVLGA DVRELPGELN DSTLGDLTTR LVQGVDFYLQ
DTKSGLDAIV CASGGWQGDP APPLEGSKDD IEKGALAYAE TIQDMLRMNL DPVLATGYLA
QQYMGPNGLL VVIGATAAIL PTPGMLGYGV SKAGAHHFVQ TMGAMTGQGL ESKSIRRQGR
KTRQYFPNLD TLHVVGILPS TIDTPSNRKA DPEANFDQWT KPLDIAKEIG SWVQKTPLRP
HSGSLVKVYT NRDRSGAGFE LVR
//
