GenomeNet

Database: UniProt
Entry: B5YLL9_THAPS
LinkDB: B5YLL9_THAPS
Original site: B5YLL9_THAPS 
ID   B5YLL9_THAPS            Unreviewed;       344 AA.
AC   B5YLL9;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=Aldo-keto oxidoreductase {ECO:0000313|EMBL:ACI64103.1};
DE            EC=1.1.1.200 {ECO:0000313|EMBL:ACI64103.1};
GN   ORFNames=THAPS_264496 {ECO:0000313|EMBL:ACI64103.1};
OS   Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC   Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC   Thalassiosiraceae; Thalassiosira.
OX   NCBI_TaxID=35128 {ECO:0000313|EMBL:ACI64103.1, ECO:0000313|Proteomes:UP000001449};
RN   [1] {ECO:0000313|EMBL:ACI64103.1, ECO:0000313|Proteomes:UP000001449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64103.1};
RX   PubMed=15459382; DOI=10.1126/science.1101156;
RA   Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA   Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA   Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA   Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA   Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA   Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA   Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA   Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA   Wilkerson F.P., Rokhsar D.S.;
RT   "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT   metabolism.";
RL   Science 306:79-86(2004).
RN   [2] {ECO:0000313|EMBL:ACI64103.1, ECO:0000313|Proteomes:UP000001449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64103.1};
RX   PubMed=18923393; DOI=10.1038/nature07410;
RA   Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA   Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA   Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA   Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA   Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA   Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA   Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA   La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA   Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA   Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA   Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA   Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA   Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA   Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA   Grigoriev I.V.;
RT   "The Phaeodactylum genome reveals the evolutionary history of diatom
RT   genomes.";
RL   Nature 456:239-244(2008).
RN   [3] {ECO:0000313|EMBL:ACI64103.1, ECO:0000313|Proteomes:UP000001449}
RP   GENOME REANNOTATION.
RC   STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64103.1};
RG   Diatom Consortium;
RA   Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA   Schmutz J., Lindquist E., Shapiro H., Lucas S., Glavina del Rio T.,
RA   Bruce D., Pitluck S., Rokhsar D., Armbrust V.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001159; ACI64103.1; -; Genomic_DNA.
DR   RefSeq; XP_002295386.1; XM_002295350.1.
DR   AlphaFoldDB; B5YLL9; -.
DR   STRING; 35128.B5YLL9; -.
DR   PaxDb; 35128-Thaps264496; -.
DR   EnsemblProtists; ACI64103; ACI64103; THAPS_264496.
DR   GeneID; 7442947; -.
DR   KEGG; tps:THAPS_264496; -.
DR   eggNOG; KOG1577; Eukaryota.
DR   HOGENOM; CLU_023205_0_0_1; -.
DR   InParanoid; B5YLL9; -.
DR   OMA; NAGAWKA; -.
DR   Proteomes; UP000001449; Chromosome 18.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0047641; F:aldose-6-phosphate reductase (NADPH) activity; IEA:UniProtKB-EC.
DR   CDD; cd19112; AKR_AKR2A1-2; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR044485; AKR2A1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF479; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:ACI64103.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001449}.
FT   DOMAIN          40..305
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        65
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         127
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            94
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   344 AA;  38050 MW;  516B1ACED1154E06 CRC64;
     MSSYAKPSNF DLSSPSACPT YKLNSGHSMP VIAYGTFRCN PGEVSPCVIN ALKAGYRHFD
     LAHVYGNEKE IGKALKQAFD EGMVTREELF ITGKLWNTDH EVNIVPKACA HSLNNLQLNY
     FDLYLIHFPV AWKHTGLDSP GWGASEFGDT PLIDTWRAME GLVESGLCKS IGVSNYPLLL
     MHDLTTQAMI KPACNQIEVH AYYQRESLVN YCLSRNISVS AHTPLGGGAA NAHQWNAVSP
     LQDPVVVGIA EAHGKSAGQV LLRYSLQRGI AVLPKSVKPR RMAENIDVFG FKLTEEEMKS
     LKALDKYVSY KTNPNPNVLQ SFRNGNPLMI STCINLLWIA IQHI
//
DBGET integrated database retrieval system