ID B5YML0_THAPS Unreviewed; 1044 AA.
AC B5YML0;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=THAPS_6826 {ECO:0000313|EMBL:ACI64827.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:ACI64827.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:ACI64827.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64827.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:ACI64827.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64827.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [3] {ECO:0000313|EMBL:ACI64827.1, ECO:0000313|Proteomes:UP000001449}
RP GENOME REANNOTATION.
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:ACI64827.1};
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA Schmutz J., Lindquist E., Shapiro H., Lucas S., Glavina del Rio T.,
RA Bruce D., Pitluck S., Rokhsar D., Armbrust V.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001160; ACI64827.1; -; Genomic_DNA.
DR RefSeq; XP_002296110.1; XM_002296074.1.
DR AlphaFoldDB; B5YML0; -.
DR PaxDb; 35128-Thaps6826; -.
DR EnsemblProtists; ACI64827; ACI64827; THAPS_6826.
DR GeneID; 7448992; -.
DR KEGG; tps:THAPS_6826; -.
DR eggNOG; ENOG502SCMX; Eukaryota.
DR HOGENOM; CLU_277135_0_0_1; -.
DR InParanoid; B5YML0; -.
DR OMA; KPSTHLY; -.
DR Proteomes; UP000001449; Chromosome 7.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902:SF27; INOSITOL PHOSPHATASE INTERACTING PROTEIN, ISOFORM A; 1.
DR PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449}.
FT DOMAIN 158..295
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 404..473
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 22..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 115195 MW; 52DDC88310666133 CRC64;
MSTPQISTEP QPQARIRFAD DTILPNSSSS SNQRQVLVLG PSSGDRQSTP SMQTASLDFS
MIATPGRGLD NQHEYETTPS EATGASTSVV SSGIWPSGTP FSSILRGVVS STPGMKPRQL
LGSTPYTAAR ESISDREQAM GDADTTNDEC TALAFARSAP LSGYLRKLGK NIPTFKRRFF
VLKPSTHLYY FMSPTDVEPR GCIDLDLVHD HGEGGGCEVR EIGVLPDGTF RFELLFDEEA
DDDDTKSYND EASETGSRAS QGSKKKAFQK QSIVLEARTE EIGREWMAKL QTERLSAARD
EVDFIKTNLA ETRALCSKWE QSAHNEGARA DNAEKQRDLA FSEVKLWEGK LNELNEAVGL
LAKHAAQTSD FNPDSLTEAL EGLDVNGTNF GEAFDALKKI HIDYNMALKR VEKAETRATE
FEQRTNDAGE RLAKAEAQLG EVWEDNCSIQ KELKKARREK KILVKEVRAL HANAAETQKN
QIQSTQACSR ASSRQQVYPS DNQTNSVGDA SGTAFYPSQK RALMEDERRL VIELEEHVMS
GLRLSEQFLT LNGIEPSLVG DGMDDSCMQP SHSSQERQPD NLSPVRHDAV EHNQLCSLLD
DDDDVDDDST DADVNQTVQE SETTTSLGLG SKGGDDAQTN HHNIIDDGSI HDADFRVAAE
SVQEPSRQKD DPYLYYKKQL DENRVSQNLY SRFTQTYNEK RDTDNRDAAQ QPTIQSEESS
LYHAPPSVGV ESSVSCSSRS LITDNGYATT KLECALRDVG ETPKTHRPRS SVGDDGKVYH
ITFYSSKIGL QFQKVPVEKG SVGLLTDAMT ADHGLSVETN QTASELRRIA SISQHFQTRR
QQKDQPLECL PIPPVDAVLV CGFVGFDDST GNIRPKIGAR LVAFDGIPVE VGKWTFESIR
KSIQARGRPL TLSFRNDFLT PNQRAILTKA VNDVKAYAPP RSQHNSHVAT KTSNKAFGTS
DRPTALTSST SSVSSSSQSH KYYSFSEAGS SISSTVVPLM SNLMKGVSTG KHRQQEDFTP
DYLLRQSDSL NNMRHHQDFK SSLL
//
