ID B5ZAK9_UREU1 Unreviewed; 510 AA.
AC B5ZAK9;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=UUR10_0036 {ECO:0000313|EMBL:ACI60271.1};
OS Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae; Ureaplasma.
OX NCBI_TaxID=565575 {ECO:0000313|EMBL:ACI60271.1, ECO:0000313|Proteomes:UP000002018};
RN [1] {ECO:0000313|EMBL:ACI60271.1, ECO:0000313|Proteomes:UP000002018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33699 / Western {ECO:0000313|Proteomes:UP000002018};
RA Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.;
RT "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001184; ACI60271.1; -; Genomic_DNA.
DR RefSeq; WP_012560330.1; NC_011374.1.
DR AlphaFoldDB; B5ZAK9; -.
DR STRING; 565575.UUR10_0036; -.
DR REBASE; 19119; M.Uur10ORF36P.
DR GeneID; 45015592; -.
DR KEGG; uue:UUR10_0036; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_4_1_14; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000002018; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 14..148
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 158..467
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 465..510
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 510 AA; 59047 MW; 08FF53D9A703849C CRC64;
MENNKQTKIN IDDIANDLWA SCDELRGNIS SEQYMHIIIG IIFLKTISDK YNYAINALKD
KYKDKFNDSI KNDSDLISEF FPLGLIVPDE AHWNYISGFT TDSSIGEKID QAFLKIENQN
PRLKGLFNKQ YNSPELDKTR LGNVVRKFND YDFSQFNEDL VGRIYEYFLG EFFRKQGQKG
GEFYTPKTVV ELLIDILDPN DNIKMYDPAC GTGGMFVQAR NYLHEQNKDY NKLVIYGQEY
QSQTWKLAKI NLLLNGFNEN DIHLGRGSED TFKEDLHKGQ KFDIIVANPP FNLKKWYREE
LLNDERFSWG MPPENNANYA WLLHIISKLN SRGKAGVILA NGSLSSSNKE ESLLRKKMIE
ENIVDAIISL PDKLFYTTQI SASIWFFNKN KENENVLFIE ASKMGELKTK KLRFLTKDNI
SKIKNVYDKH EQGEDVNVVG FAKTCTIDEI IENDYSLVPG RYVGFEQEVI DHEQLNHEIK
GLQEELSVLF DELEDLIPQA KESIKKVLEK
//
