ID B5ZB95_UREU1 Unreviewed; 537 AA.
AC B5ZB95;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=CTP synthase (glutamine hydrolyzing) {ECO:0000256|ARBA:ARBA00012291};
DE EC=6.3.4.2 {ECO:0000256|ARBA:ARBA00012291};
GN Name=pyrG {ECO:0000313|EMBL:ACI60261.1};
GN OrderedLocusNames=UUR10_0282 {ECO:0000313|EMBL:ACI60261.1};
OS Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX NCBI_TaxID=565575 {ECO:0000313|EMBL:ACI60261.1, ECO:0000313|Proteomes:UP000002018};
RN [1] {ECO:0000313|EMBL:ACI60261.1, ECO:0000313|Proteomes:UP000002018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33699 / Western {ECO:0000313|Proteomes:UP000002018};
RA Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.;
RT "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-
CC glutamate + phosphate; Xref=Rhea:RHEA:26426, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000314};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway;
CC CTP from UDP: step 2/2. {ECO:0000256|ARBA:ARBA00005171}.
CC -!- SIMILARITY: Belongs to the CTP synthase family.
CC {ECO:0000256|ARBA:ARBA00007533}.
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DR EMBL; CP001184; ACI60261.1; -; Genomic_DNA.
DR RefSeq; WP_004025711.1; NC_011374.1.
DR AlphaFoldDB; B5ZB95; -.
DR STRING; 565575.UUR10_0282; -.
DR GeneID; 45015830; -.
DR KEGG; uue:UUR10_0282; -.
DR eggNOG; COG0504; Bacteria.
DR HOGENOM; CLU_011675_5_0_14; -.
DR OMA; EFNNAYR; -.
DR OrthoDB; 9801107at2; -.
DR UniPathway; UPA00159; UER00277.
DR Proteomes; UP000002018; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003883; F:CTP synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd03113; CTPS_N; 1.
DR CDD; cd01746; GATase1_CTP_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR004468; CTP_synthase.
DR InterPro; IPR017456; CTP_synthase_N.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR033828; GATase1_CTP_Synthase.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00337; PyrG; 1.
DR PANTHER; PTHR11550; CTP SYNTHASE; 1.
DR PANTHER; PTHR11550:SF0; CTP SYNTHASE-RELATED; 1.
DR Pfam; PF06418; CTP_synth_N; 1.
DR Pfam; PF00117; GATase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACI60261.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}.
FT DOMAIN 8..271
FT /note="CTP synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06418"
FT DOMAIN 308..524
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
SQ SEQUENCE 537 AA; 60610 MW; 160755EEF8430819 CRC64;
MKHKQKTKFI FVTGGVYSSL GKGVSASSIG RILVELGYSV AMQKLDPYLN IDPTYLSPLQ
HGEVFVTKDG KEADLDLGTY ERFINADLNK YSSVTSGKIY YEILTKEREN GFGGKTVQTI
PHITSAVIDY IEKIKDSLKT DFVIVEIGGT IGDIESLPFI EAISQFKTIY GANNVMFIHC
SPLIYIEKVG ELKTKPTQHS VKILRSLGIS LDLLLLRTDQ KLDEVTIKKL AWSCGLDVDM
IFAAYDVESV YLLPNILFEQ GIHKAILEFF DLPLKNDNIN SWISFTNKII IPKKHELIIG
LVGKYVELPD AYKSVLASLE LAAIELNIDL KIKYIQPINL NENNVDDELK TLNGIVIPSI
AGSIKGWPGA LLAATYARKN NIPFLAIGTG VNIGVGEFVK NQLQLPIEFI NLGNGDFSFL
KYAFIKNEIE NYRIGEYCSN IQVNTITSKI YCEQKQLNER HRHHFEFNSE YINDHFLKHG
WKIGAISTNN DYIDVLEYTK NHFYVLTIFN AEYTSKPSKP NPYFINLLKT SLKIKES
//