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Database: UniProt
Entry: B6BVS5_9PROT
LinkDB: B6BVS5_9PROT
Original site: B6BVS5_9PROT 
ID   B6BVS5_9PROT            Unreviewed;       450 AA.
AC   B6BVS5;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   27-SEP-2017, entry version 63.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EDZ64837.1};
GN   ORFNames=KB13_969 {ECO:0000313|EMBL:EDZ64837.1};
OS   beta proteobacterium KB13.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   OM43 clade.
OX   NCBI_TaxID=314607 {ECO:0000313|EMBL:EDZ64837.1, ECO:0000313|Proteomes:UP000004188};
RN   [1] {ECO:0000313|Proteomes:UP000004188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KB13 {ECO:0000313|Proteomes:UP000004188};
RX   PubMed=22675594; DOI=10.4056/sigs.2305090;
RA   Huggett M.J., Hayakawa D.H., Rappe M.S.;
RT   "Genome sequence of strain HIMB624, a cultured representative from the
RT   OM43 clade of marine Betaproteobacteria.";
RL   Stand. Genomic Sci. 6:11-20(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; DS995299; EDZ64837.1; -; Genomic_DNA.
DR   RefSeq; WP_009852828.1; NZ_DS995299.1.
DR   ProteinModelPortal; B6BVS5; -.
DR   STRING; 314607.KB13_969; -.
DR   EnsemblBacteria; EDZ64837; EDZ64837; KB13_969.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004188; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004188};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004188}.
FT   DOMAIN      147    278       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      358    427       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     155    162       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51716 MW;  683B23527F800007 CRC64;
     MKTEEFWEII STQLKKKLTA QQFKTWVKPL SIREKEDSLE IVAPNQFIQQ WVTDRFSKEI
     IEIGKEHKIK NKILFVTEKG KKNSKPTNTS EEKNDVKPKV EDRAPKAVIN KSTGLNKNLN
     FENFVTGRAN QLATAAAKQV SERPGESYNP LFIYGGVGLG KTHLLQSIGN KVKEENKDFK
     IKYLHAERYV TDVVKAYEGK TFDQFKKNYH SLDLLLIDDI QFIGKKNRTQ EEFFYAFNTL
     IENKKQIIIT CDSYPKEIQG VDERLRTRFS WGLTVAIEPP ELEMRVAILL KKAEISKITL
     PEDVAFFIAK QIRSNVRELE GALNRIVALS NFTNLPIDLN LAKEALKDLI AVRGRQVTIE
     NIQKTVADYY KIKISDMVGK KRSRNFSKPR QVAMALTREL TNLSYPEIGN YFGGRHHTTV
     MHACEEIEEQ RLNNQSLGQD LGFLTQVLRG
//
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