ID B6CN61_9NEOP Unreviewed; 355 AA.
AC B6CN61;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Elongation factor 1-alpha {ECO:0000313|EMBL:ACD75931.1};
DE Flags: Fragment;
GN Name=EF1a {ECO:0000313|EMBL:ACD75931.1};
OS Ceratophyllus gallinae (common hen flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Siphonaptera; Ceratophyllidae; Ceratophyllus.
OX NCBI_TaxID=217689 {ECO:0000313|EMBL:ACD75931.1};
RN [1] {ECO:0000313|EMBL:ACD75931.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=F035 {ECO:0000313|EMBL:ACD75931.1};
RA Whiting M.F., Whiting A.S., Hastriter M.W., Dittmar K.;
RT "A molecular phylogeny of fleas (Insecta: Siphonaptera): origins and host
RT associations.";
RL Cladistics 24:677-707(2008).
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003982}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR EMBL; EU336255; ACD75931.1; -; Genomic_DNA.
DR AlphaFoldDB; B6CN61; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF236; ELONGATION FACTOR 1-ALPHA 1; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:ACD75931.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|EMBL:ACD75931.1}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACD75931.1"
FT NON_TER 355
FT /evidence="ECO:0000313|EMBL:ACD75931.1"
SQ SEQUENCE 355 AA; 38539 MW; 85305700CCE3408D CRC64;
IDIALWKFET AKYYVTIIDA PGHRDFIKNM ITGTSQADCA VLIVAAGVGE FEAGISKNGQ
TREHALLAFT LGVKQLIVGV NKMDSTEPPY SENRFEEIKK EVSSYIKKIG YNPAAVAFVP
ISGWHGDNML EVSTKMSWFK GWNVERKEGK ADGKCLIEAL DAILPPARPT DKALRLPLQD
VYKIGGIGTV PVGRVETGVL KPGTVVVFAP ANITTEVKSV EMHHEALQEA VPGDNVGFNV
KNVSVKELRR GYVAGDSKAS PPRGAADFTA QVIVLNHPGQ ISNGYTPVLD CHTAHIACKF
AEIKEKVDRR TGKSTEENPK AIKSGDAAIV NLVPSKPMCV ESFQEFPPLG RFAVR
//
