ID   B6CY46_9SAUR            Unreviewed;       175 AA.
AC   B6CY46;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:ACF05587.1};
OS   Uroplatus malahelo.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Gekkota; Gekkonidae; Gekkoninae;
OC   Uroplatus.
OX   NCBI_TaxID=402379 {ECO:0000313|EMBL:ACF05587.1};
RN   [1] {ECO:0000313|EMBL:ACF05587.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Raxworthy C.J., Pearson R.G., Zimkus B.M., Reddy S., Deo A.J.,
RA   Nussbaum R.A., Ingram C.M.;
RT   "Continental speciation in the tropics: contrasting biogeographic patterns
RT   of divergence in the Uroplatus leaf-tailed gecko radiation of Madagascar.";
RL   J. Zool. 275:423-440(2008).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; EU596894; ACF05587.1; -; Genomic_DNA.
DR   AlphaFoldDB; B6CY46; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          97..175
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACF05587.1"
FT   NON_TER         175
FT                   /evidence="ECO:0000313|EMBL:ACF05587.1"
SQ   SEQUENCE   175 AA;  19671 MW;  136A325C234744EC CRC64;
     GLRTQGTLEN LGGPNDASRG LTSLADTFEH VIEELLDEQQ DIQPSKENKD ADLYSSRVML
     SSQVPLEPPL LFLLEEYKNY LDAANMSMRV RRHSDPARRG ELSVCDSTSE WVTAAEKKTA
     VDMSGATVTV LEKVPVPKGQ LKQYFYETKC NSKGYTKEGC RGIDKRYWNS QCRTT
//