ID B6CYZ6_9LABR Unreviewed; 123 AA.
AC B6CYZ6;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Distal-less homeobox 2 {ECO:0000313|EMBL:ACF53870.1};
DE Flags: Fragment;
GN Name=DLX2 {ECO:0000313|EMBL:ACF53870.1};
OS Scarus quoyi (Quoy's parrotfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Scarines; Scarus.
OX NCBI_TaxID=247626 {ECO:0000313|EMBL:ACF53870.1};
RN [1] {ECO:0000313|EMBL:ACF53870.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18621133; DOI=10.1016/j.ympev.2008.06.008;
RA Smith L.L., Fessler J.L., Alfaro M.E., Streelman J.T., Westneat M.W.;
RT "Phylogenetic relationships and the evolution of regulatory gene sequences
RT in the parrotfishes.";
RL Mol. Phylogenet. Evol. 49:136-152(2008).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family.
CC {ECO:0000256|ARBA:ARBA00007916}.
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DR EMBL; EU601538; ACF53870.1; -; Genomic_DNA.
DR AlphaFoldDB; B6CYZ6; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043009; P:chordate embryonic development; IEA:UniProt.
DR GO; GO:0048598; P:embryonic morphogenesis; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24327:SF23; HOMEOBOX PROTEIN DLX-2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 8..68
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 10..69
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 75..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF53870.1"
FT NON_TER 123
FT /evidence="ECO:0000313|EMBL:ACF53870.1"
SQ SEQUENCE 123 AA; 13881 MW; 6BC76C6F8A8207EE CRC64;
RMVNGKPKKV RKPRTIYSSF QLAALQRRFQ KTQYLALPER AELAASLGLT QTQVKIWFQN
RRSKFKKLWK SGEIPPEQHV ATSESPPCSS PPTTAWDFPQ TQRMNSVNSS LPQSSSPPNT
AAP
//
