ID B6D688_HBV Unreviewed; 54 AA.
AC B6D688;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
DE Flags: Fragment;
GN Name=C {ECO:0000256|RuleBase:RU361253, ECO:0000313|EMBL:ACI43609.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ACI43609.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ACI43609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=15 {ECO:0000313|EMBL:ACI43609.1};
RX PubMed=19651540; DOI=10.1016/j.jcv.2009.07.005;
RA Tangkijvanich P., Komolmit P., Mahachai V., Sa-nguanmoo P.,
RA Theamboonlers A., Poovorawan Y.;
RT "Low pretreatment serum HBsAg level and viral mutations as predictors of
RT response to PEG-interferon alpha-2b therapy in chronic hepatitis B.";
RL J. Clin. Virol. 46:117-123(2009).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells.
CC {ECO:0000256|RuleBase:RU361253}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000256|RuleBase:RU361253}.
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DR EMBL; EU841370; ACI43609.1; -; Genomic_DNA.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 1.
DR SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT DOMAIN 1..27
FT /note="Hepatitis B virus capsid N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08290"
FT NON_TER 54
FT /evidence="ECO:0000313|EMBL:ACI43609.1"
SQ SEQUENCE 54 AA; 6035 MW; 8FC6D4B3A77DBEBC CRC64;
MQLFHLCLII SCSCPTVQAS KLCLGWLWGT DIDPYKEFGA SVEILSFLPS DFLP
//