ID   B6DU81_LEIME            Unreviewed;       440 AA.
AC   B6DU81;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Metacaspase {ECO:0000313|EMBL:ACI23361.1};
GN   Name=MCA5 {ECO:0000313|EMBL:ACI23361.1};
OS   Leishmania mexicana.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5665 {ECO:0000313|EMBL:ACI23361.1};
RN   [1] {ECO:0000313|EMBL:ACI23361.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Balanco J.M.F., Cortez A.P., Teixeira M.M.G., Winter C.E., Barcinski M.A.;
RT   "Metacaspase gene (MCA5) of twelve different species of Leishmania.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family.
CC       {ECO:0000256|ARBA:ARBA00009005}.
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DR   EMBL; FJ169616; ACI23361.1; -; Genomic_DNA.
DR   AlphaFoldDB; B6DU81; -.
DR   MEROPS; C14.043; -.
DR   VEuPathDB; TriTrypDB:LmxM.34.1580; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.12660; -; 1.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR   PANTHER; PTHR48104; METACASPASE-4; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          63..307
FT                   /note="Peptidase C14 caspase"
FT                   /evidence="ECO:0000259|Pfam:PF00656"
FT   REGION          393..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..440
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  48197 MW;  B538E1DEAB71D72B CRC64;
     MADLFDILGI GAVATLIPML ANGLLLVDRP KRVDINAGRR LIHTVRPIIP YRAPVPYTGG
     RVRALFIGIN YTGTRNALRG CVNDVGSMLG TLQQITFPIS ECCILVDDPS FPGFSAMPTR
     ENIIKHMLWL TGDVRPGDVL FFHFSGHGGQ TKAKRDTEEK YDQCLIPLDH IENGSILDDD
     LFLMLVAPLP PGVRMTCVFD CCHSASMLDL PFSYVTPRVG GGGAREYMQQ VRRGNFSNGD
     VVMFSGCTDS GTSADVQNGG HANGAATLAF TWSLLNTHGF SYLNILLKTR EELRKKGRVQ
     VPQLTSSKPI DLYKPFSLFG MITVNTSMMH CVPQQYQQPP QSLPPQAMPP PMGYPAYVPR
     PPQSYYPPPQ RRVWGSGYPA QEYLAQRIPV QQATPGVSGC PTSQYLPAPP SAPYAPPPPA
     QYGPQQPPPA QYTFGPLPPR
//