ID   B6DU87_LEICH            Unreviewed;       448 AA.
AC   B6DU87;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Metacaspase {ECO:0000313|EMBL:ACI23367.1};
GN   Name=MCA5 {ECO:0000313|EMBL:ACI23367.1};
OS   Leishmania chagasi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=44271 {ECO:0000313|EMBL:ACI23367.1};
RN   [1] {ECO:0000313|EMBL:ACI23367.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Balanco J.M.F., Cortez A.P., Teixeira M.M.G., Winter C.E., Barcinski M.A.;
RT   "Metacaspase gene (MCA5) of twelve different species of Leishmania.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family.
CC       {ECO:0000256|ARBA:ARBA00009005}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FJ169622; ACI23367.1; -; Genomic_DNA.
DR   AlphaFoldDB; B6DU87; -.
DR   MEROPS; C14.043; -.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.12660; -; 1.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR   PANTHER; PTHR48104; METACASPASE-4; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
PE   3: Inferred from homology;
FT   DOMAIN          63..307
FT                   /note="Peptidase C14 caspase"
FT                   /evidence="ECO:0000259|Pfam:PF00656"
FT   REGION          335..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..379
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..448
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   448 AA;  48723 MW;  376BBF71088D660C CRC64;
     MADLFDILGI GAVASLIPML ANGLLLVDRP KRVDINAGRR LIHTVRPMIP YRAPVPYTGG
     RVRALFIGIN YTGMRNALRG CVNDVSSMLG TLQQISFPIS ECCILVDDPS FPGFCGMPTR
     DNIIKHMLWL TGDVRPGDVL FFHFSGHGGQ TKATRDSEEK YDQCLIPLDH VKNGSILDDD
     LFLMLVAPLP SGVRMTCVFD CCHSASMLDL PFSYVAPRVG GGGAREYMQQ VRRGNFSNGD
     VVMFSGCTDS GTSADVQNGG HANGAATLAF TWSLLNTHGF SYLNILLKTR EELRKKGRVQ
     VPQLTSSKPI DLYKPFSLFG MITVNASMMH CVPQQYQQRP QSLPPQAMPP PAGYPVHVPP
     PPQGYYPPPP QGYYPPPQRP GWGLGYPAPG YPAQGIPVQQ ATLGVSRCPP SQYLPAPPPA
     LYAPPPPGQH GPPQPPPAQY TFSPLPPR
//